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  1. Article

    Open Access

    Inotuzumab ozogamicin for relapsed/refractory acute lymphoblastic leukemia: outcomes by disease burden

    Adults with relapsed/refractory acute lymphoblastic leukemia (R/R ALL) have a poor prognosis, especially if disease burden is high. This post hoc analysis of the phase 3 INO-VATE trial examined the efficacy an...

    Daniel J. DeAngelo, Anjali S. Advani, David I. Marks… in Blood Cancer Journal (2020)

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  2. Article

    Open Access

    Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells

    Approximately 1,000 microRNAs (miRs) are present in the human genome; however, little is known about the regulation of miR transcription. Because miR levels are deregulated in chronic lymphocytic leukemia (CLL...

    Uri Rozovski, George A Calin, Tetsuro Setoyama, Lucilla D’Abundo… in Molecular Cancer (2013)

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  3. Article

    Open Access

    Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome

    Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide...

    Wanlong Ma, Hagop Kantarjian, Ke Zhang, ** Zhang, **uqiang Wang… in BMC Medical Genetics (2010)

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  4. No Access

    Article

    A Guide to the Use of Interferon-Alpha in the Management of Chronic Myelogenous Leukaemia

    Interferon-alpha (IFNα) can induce major cytogenetic responses in 30 to 40% of patients with chronic myelogenous leukaemia (CML) and up to 50% when combined with cytarabine (ara-C). These responses translate i...

    Dr Jorge Cortes, Susan O’Brien in BioDrugs (2000)