12 Result(s)
within
Susan J. Clark
Oncology
-
Article
Open AccessEpigenomics of mammary gland development
Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of ...
-
Article
Open AccessMicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene
The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary devel...
-
Article
Open AccessProfiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways
Although aberrant tyrosine kinase signalling characterises particular breast cancer subtypes, a global analysis of tyrosine phosphorylation in mouse models of breast cancer has not been undertaken to date. Thi...
-
Article
Open AccessZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer
We previously identified that the CpG island-associated promoter of the novel lincRNA ZNF300P1 (also known as LOC134466) is frequently hypermethylated and silenced in ovarian cancer tissues. However, the function...
-
Article
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis
Epigenetic gene regulation has influence over a diverse range of cellular functions, including the maintenance of pluripotency, differentiation, and cellular identity, and is deregulated in many diseases, incl...
-
Article
Open AccessAndrogen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events
Breast cancer outcome, including response to therapy, risk of metastasis and survival, is difficult to predict using currently available methods, highlighting the urgent need for more informative biomarkers. A...
-
Chapter and Conference Paper
Epigenetic Markers of Ovarian Cancer
Ovarian cancer is the fourth leading cause of cancer death in women, and has the highest mortality rate of the reproductive cancers (1). Ovarian cancer is often asymptomatic in its early stages and because of ...
-
Article
Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy
Inactivation of specific tumor suppressor genes by transcriptional silencing associated with hypermethylation of the promoter is a common event in cancer. We have applied the amplification of intermethylated s...
-
Article
Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts
Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of...
-
Article
DNA methylation and gene silencing in cancer: which is the guilty party?
The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characte...
-
Article
Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells
Understanding what triggers hypermethylation of tumour suppressor genes in cancer cells is critical if we are to discern the role of methylation in the oncogenic process. CpG sites in CpG island promoters, tha...
-
Article
Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer
Glutathione-S-Transferases (GSTs) comprise a family of isoenzymes that provide protection to mammalian cells against electrophilic metabolites of carcinogens and reactive oxygen species. Previous studies have ...
