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  1. No Access

    Article

    Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy

    Inactivation of specific tumor suppressor genes by transcriptional silencing associated with hypermethylation of the promoter is a common event in cancer. We have applied the amplification of intermethylated s...

    Jordi Frigola, Mar Muñoz, Susan J Clark, Victor Moreno, Gabriel Capellà… in Oncogene (2005)

  2. No Access

    Article

    Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

    Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of...

    Jane R Noble, Ze-Huai Zhong, Axel A Neumann, John R Melki, Susan J Clark… in Oncogene (2004)

  3. No Access

    Article

    DNA methylation and gene silencing in cancer: which is the guilty party?

    The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characte...

    Susan J Clark, John Melki in Oncogene (2002)

  4. No Access

    Article

    Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells

    Understanding what triggers hypermethylation of tumour suppressor genes in cancer cells is critical if we are to discern the role of methylation in the oncogenic process. CpG sites in CpG island promoters, tha...

    Jenny Z Song, Clare Stirzaker, Janet Harrison, John R Melki, Susan J Clark in Oncogene (2002)

  5. No Access

    Article

    Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer

    Glutathione-S-Transferases (GSTs) comprise a family of isoenzymes that provide protection to mammalian cells against electrophilic metabolites of carcinogens and reactive oxygen species. Previous studies have ...

    Douglas S Millar, Kim K Ow, Cheryl L Paul, Pamela J Russell, Peter L Molloy… in Oncogene (1999)