40 Result(s)
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Article
Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts
Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-...
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Article
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women
We examined the association of plasma B-vitamins and metabolites, and related genetic variants, with risk of breast cancer among predominantly premenopausal women.
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Pre-diagnostic sex hormone levels and survival among breast cancer patients
Higher levels of circulating sex steroid hormones are associated with increased breast cancer risk, though their association with prognosis remains unclear. We evaluated the association between circulating sex...
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Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues
In post-menopausal women, high body mass index (BMI) is an established breast cancer risk factor and is associated with worse breast cancer prognosis. We assessed the associations between BMI and gene expressi...
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Article
Circulating Hormones and Mammographic Density in Premenopausal Women
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic...
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Article
Breast cancer risk prediction: an update to the Rosner–Colditz breast cancer incidence model
To update and expand the Rosner–Colditz breast cancer incidence model by evaluating the contributions of more recently identified risk factors as well as predicted percent mammographic density (MD) to breast c...
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Extensions of the Rosner-Colditz breast cancer prediction model to include older women and type-specific predicted risk
A breast cancer risk prediction rule previously developed by Rosner and Colditz has reasonable predictive ability. We developed a re-fitted version of this model, based on more than twice as many cases now inc...
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Accounting for individualized competing mortality risks in estimating postmenopausal breast cancer risk
Accurate risk assessment is necessary for decision-making around breast cancer prevention. We aimed to develop a breast cancer prediction model for postmenopausal women that would take into account their indiv...
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Article
Plasma fluorescent oxidation products and risk of estrogen receptor-negative breast cancer in the Nurses’ Health Study and Nurses’ Health Study II
Findings from epidemiologic studies of oxidative stress biomarkers and breast cancer have been mixed, although no studies have focused on estrogen receptor-negative (ER−) tumors which may be more strongly asso...
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Article
Healthy dietary patterns and risk of breast cancer by molecular subtype
We examined associations between dietary quality indices and breast cancer risk by molecular subtype among 100,643 women in the prospective Nurses’ Health Study (NHS) cohort, followed from 1984 to 2006. Dieta...
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Article
Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women
In a cross-sectional analysis, we evaluated the associations of usual total alcohol and wine intake with a comprehensive profile of mid-luteal phase urinary estrogens and estrogen metabolites (referred to join...
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Article
Alcohol Consumption and Risk of Breast Cancer by Tumor Receptor Expression
In epidemiologic studies, alcohol consumption appears more strongly associated with risk of estrogen receptor (ER)-positive than ER-negative breast cancer. However, this association has not been assessed by ot...
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Article
Open AccessShort-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women
Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change i...
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Article
The Relationship Between Bilateral Oophorectomy and Plasma Hormone Levels in Postmenopausal Women
Oophorectomy prior to natural menopause reduces breast cancer risk. We evaluated whether timing of oophorectomy (during premenopause vs. postmenopause) or hysterectomy was associated with hormone levels, speci...
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Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer
Epidemiologic evidence for an association between plasma 25-hydroxyvitamin D [25(OH)D] and breast cancer is inconsistent. Data are especially limited for premenopausal women and for associations with mammograp...
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Article
Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses’ Health Studies
Higher circulating prolactin levels have been associated with higher percent mammographic density among postmenopausal women in some, but not all studies. However, few studies have examined associations with d...
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Article
The Association of Reproductive and Lifestyle Factors with a Score of Multiple Endogenous Hormones
We recently reported that high levels of multiple sex and growth hormones were associated with increased postmenopausal breast cancer risk. Limited research has explored the relationship between reproductive, ...
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Article
Digoxin use and risk of invasive breast cancer: evidence from the Nurses’ Health Study and meta-analysis
Despite preclinical evidence supporting anti-cancer effects of cardiac glycosides, epidemiologic studies consistently show elevated breast cancer risk in digoxin users. We studied this association in the Nurs...
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Article
Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women
Analgesic use has been hypothesized to reduce the risk of some cancers, with inverse associations between analgesics and colon cancer, and suggestive inverse associations for breast cancer. Estrogen metabolite...
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