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Article
Open AccessCharge transfer mechanism for realization of double negative differential transconductance
With development of information age, multi-valued logic (MVL) technology utilizing negative differential transconductance (NDT) phenomenon has drawn attention as next-generation computing technology that can r...
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Article
Open AccessRole of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling and the excessive accumulation of extracellular matrix (ECM) proteins. In a previous study, we found that the levels of ornithin...
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Article
Open AccessDiscovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of ...
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Article
Open AccessCT texture features and lung shunt fraction measured using 99mTc-macroaggregated albumin SPECT/CT before trans-arterial radioembolization for hepatocellular carcinoma patients
The aim of this study is to determine whether contrast-enhanced computed tomography (CECT)-based texture parameters can predict high (> 30 Gy) expected lung dose (ELD) calculated using 99mTc macroaggregated album...
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Article
Open AccessThe experience and reflections of GC labs as an independent clinical laboratory to the COVID-19 pandemic in South Korea
Amid the COVID-19 pandemic, extensive testing was undertaken by independent clinical laboratories (ICLs), yet limited research exists on this matter. Drawing from Green Cross Laboratories (GC Labs)' pandemic r...
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Article
Open AccessDevelopment of pediatric simulation-based education – a systematic review
This systematic literature review explored the general characteristics, validation, and reliability of pediatric simulation-based education (P-SBE).
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Article
Open AccessIntronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences
Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced ...
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Article
Open AccessDeep learning regressor model based on nigrosome MRI in Parkinson syndrome effectively predicts striatal dopamine transporter-SPECT uptake
Nigrosome imaging using susceptibility-weighted imaging (SWI) and dopamine transporter imaging using 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single-photon emission compu...
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Article
Open AccessQuantitative Iodine-123 single-photon emission computed tomography/computed tomography for Iodine-131 therapy of an autonomously functioning thyroid nodule
Autonomously functioning thyroid nodules (AFTNs) are treated with iodine-131 (I-131) therapy, which increases the risk of permanent hypothyroidism; however, the risk can be reduced by separately estimating the...
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Knee Prostheses
Knee surgeries can be classified as joint-preserving surgeries such as osteotomy, ligament reconstruction, meniscus repair, and cartilage repair, and joint-replacing arthroplasties such as unicondylar knee art...
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Article
Open AccessBiodistribution and internal radiation dosimetry of a companion diagnostic radiopharmaceutical, [68Ga]PSMA-11, in subcutaneous prostate cancer xenograft model mice
[68Ga]PSMA-11 is a prostate-specific membrane antigen (PSMA)-targeting radiopharmaceutical for diagnostic PET imaging. Its application can be extended to targeted radionuclide therapy (TRT). In this study, we cha...
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Article
Verification of Operating Principle of Nano Field-effect Transistor Biosensor with an Extended Gate Electrode
Many studies have been conducted on the use of nano field-effect transistor (nanoFET) sensors for the detection of biological species. However, the practical application of nanoFET-based biosensors is difficul...
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Article
Open AccessSpermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice
Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiaging, and cell growth-promoting effects. We previously reported that spermidine leve...
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Article
Pharmacological inhibition of androgen receptor expression induces cell death in prostate cancer cells
The androgen receptor (AR) plays an important role in the pathogenesis and development of prostate cancer (PCa). Mostly, PCa progresses to androgen-independent PCa, which has activated AR signaling from androg...
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Article
Sensitivity Improvement in Electrochemical Immunoassays Using Antibody Immobilized Magnetic Nanoparticles with a Clean ITO Working Electrode
We report a dramatic improvement in the detection sensitivity of electrochemical immunosensors through the use of a magnetic nanoparticle for immunoassay reactions and an ITO working electrode for measurement ...
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Article
Open AccessTetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia
By comparing imatinib-sensitive and -resistant chronic myeloid leukemia (CML) cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-depende...
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Article
Perspectives in TSPO PET Imaging for Neurologic Diseases
The translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been don...
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Article
Electrochemical Immunoassay Based on Indium Tin Oxide Activity Toward a Alkaline Phosphatase
In vitro diagnostic technologies, used to evaluate disease status at the point-of-care (POC), are of urgent importance to improve diagnostic capabilities in bladder cancer. However, currently available approaches...
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Article
Open AccessNovel crosstalk between Vps26a and Nox4 signaling during neurogenesis
Despite numerous studies on the molecular switches governing the conversion of stemness to differentiation in embryonic stem cells (ESCs), little is known about the involvement of the retromer complex. Under n...
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Article
Open AccessReflective color filter with precise control of the color coordinate achieved by stacking silicon nanowire arrays onto ultrathin optical coatings
The engineering of structural colors is currently a promising, rapidly emerging research field because structural colors of outstanding spatial resolution and durability can be generated using a sustainable pr...
