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Article
Open AccessMolecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistance
Mediators, genomic and epigenomic characteristics involving in metabolism of arachidonic acid by cyclooxygenase (COX) and lipoxygenase (ALOX) and hepatic activation of clopidogrel have been individually sugges...
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Article
Fabrication of composite microbeads consisting of cellulose and covalent organic nanosheets via electrospray process
Microplastics including microbeads that are heavily utilized in our daily necessities such as cleaners, toothpastes, and cosmetic products as well as in industrial applications have become a severe environment...
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Article
Open AccessHypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells
Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be...
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Article
Effect of NV gene deletion in the genome of hirame rhabdovirus (HIRRV) on viral replication and the type I interferon response of the host cell
Hirame rhabdovirus (HIRRV), a member of the genus Novirhabdovirus, causes morbidity and mortality in farmed olive flounder (Paralichthys olivaceus). As no information is available on the role of the NV gene of HI...
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Article
Open AccessProperties analysis of crosslinked chitosan microcapsules by multiple emulsification method
Chemical based finishing agents often affect human body and environment. Therefore, in this study, eco-friendly microcapsules were manufactured to minimize the use of chemicals by using chitosan, a natural sub...
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Article
Open AccessDirect differentiation of bone marrow mononucleated cells into insulin producing cells using pancreatic β-cell-derived components
Transplantation of stem cell-derived insulin producing cells (IPCs) has been proposed as an alternative to islet transplantation for the treatment of diabetes mellitus. However, current IPC differentiation pro...
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Article
The inability of Bacillus licheniformis perR mutant to grow is mainly due to the lack of PerR-mediated fur repression
PerR, a member of Fur family protein, is a metal-dependent H2O2 sensing transcription factor that regulates genes involved in peroxide stress response. Industrially important bacterium Bacillus licheniformis cont...
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Article
Effect of fiber diameter on surface morphology, mechanical property, and cell behavior of electrospun poly(ε-caprolactone) mat
In this study, electrospinning of poly(ε-caprolactone) (PCL) and its optimum preparation conditions were examined in detail using various solvent systems, such as formic acid, dichloromethane/dimethyl formamid...
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Article
Open AccessAlleviation of skin inflammation after Lin− cell transplantation correlates with their differentiation into myeloid-derived suppressor cells
To understand the cellular mechanism underlying the therapeutic effects exerted by hematopoietic stem cell transplantation in the repair of tissue damage, we investigated the in vivo dynamics of bone marrow (BM) ...
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Article
Open AccessMemory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
CD8+ T cells activated without CD4+ T-cell help are impaired in memory expansion. To understand the underlying cellular mechanism, here we track the dynamics of helper-deficient CD8+ T-cell response to a minor hi...
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Article
Open AccessSubdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection
In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distri...
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Article
Hypolipidemic, hypoglycemic, and antioxidative effects of a new pigmented rice cultivar “Superjami” in high fat-fed mice
Effects of newly-developed pigmented rice Superjami, in comparison with those of its parental cultivars (Heug**jubyeo and Suweon 425) and ordinary brown rice, on the lipid and glucose metabolisms and antioxid...
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Article
Porous hydroxyapatite scaffolds containing calcium phosphate glass-ceramics processed using a freeze/gel-casting technique
A freeze/gel-casting technique has been applied to produce porous ceramic composite scaffolds with tailored pore structures and improved compressive strength for tissue engineering applications. Tertiary-butyl...
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Article
Open AccessMechanisims of asthma and allergic disease – 1093. A novel human anti-VCAM-1 Monoclonal antibody Ameliorates airway inflammation and remodeling in murine asthma model
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Article
A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment
TCR of CD8 T cells recognizes peptides of 8–9 amino acids in length (epitope) complexed with MHC class I. Peptide ligands differing from an epitope by one or two amino acids are thought to modulate the immune ...
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Article
Optimum design of an active micro-mixer using successive Kriging method
In this microfluidic application, microfluidic analysis of an active micro-mixer with an oscillating stirrer in a straight microchannel was performed. The effects of molecular diffusion and disturbance by the ...
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Article
Effects of cell-seeding methods of human osteoblast culture on biomechanical properties of porous bioceramic scaffold
Many studies have been performed to accelerate osteoinduction and osteoconduction into porous ceramic scaffolds by seeding them with cells. In this study, we compared available cell-seeding methods on a porous...
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Article
Preparation and characterization of nanofibrous membranes of poly(D,L-lactic acid)/chitin blend for guided tissue regenerative barrier
Nanofibrous membranes of poly(D,L-lactic acid)/chitin blend were prepared by electrospinning for a barrier of guided tissue regeneration. A miscible solution was obtained by the blending chitin-salt complex in...
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Article
Preparation of High Flexible Composite Film of Hydroxyapatite and Chitosan
Microscale hydroxyapatite (HAp), a well-known biocompatible substance for the regeneration and reinforcement of damaged bones, was composited with chitosan as a counter-polymer to produce a film with both bioc...
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Article
Anthocyanin content in rice is related to expression levels of anthocyanin biosynthetic genes
The composition of anthocyanins was analyzed in two rice cultivais, ‘llpum’ showed no detectable levels, while ‘Heug**ju’ contained three types of anthocyanins: cyanidin, cyanidin 3-O-glucoside, and peonidin ...
