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  1. Article

    Open Access

    Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

    The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acq...

    Tobias Welte, R. Phillip Dellinger, Henning Ebelt, Miguel Ferrer… in Intensive Care Medicine (2018)

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  2. No Access

    Article

    Sepsis: frontiers in supportive care, organisation and research

    Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-...

    Anders Perner, Andrew Rhodes, Bala Venkatesh, Derek C. Angus… in Intensive Care Medicine (2017)

  3. Article

    Should all septic patients be given systemic anticoagulation? No

    Tom van der Poll, Steven M. Opal in Intensive Care Medicine (2017)

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  4. Article

    Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

    To provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.

    R. P. Dellinger, Mitchell M. Levy, Andrew Rhodes… in Intensive Care Medicine (2013)

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  5. No Access

    Article

    Coagulation in sepsis

    Coagulation abnormalities, ranging from a simple fall in platelet count to full-blown disseminated intravascular coagulation, are a common occurrence in critically ill patients and have been associated with i...

    André Amaral, Steven M. Opal, Jean-Louis Vincent in Intensive Care Medicine (2004)

  6. No Access

    Article

    2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

    In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were to "provide a conceptual and a practical fra...

    Mitchell M. Levy, Mitchell P. Fink, John C. Marshall… in Intensive Care Medicine (2003)