11 Result(s)

Article

Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma

The role of the tumor microenvironment (TME) and intratumoral T cells in splenic marginal zone lymphoma (sMZL) is largely unknown. In the present study, we evaluated 36 sMZL spleen specimens by single cell ana...

Theodora Anagnostou, Zhi-Zhang Yang, Shahrzad Jalali, Hyo ** Kim… in Leukemia (2023)

Article

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtyp...

Sonja I. Berndt, Joseph Vijai, Yolanda Benavente, Nicola J. Camp… in Leukemia (2022)

Article

High-dimensional and single-cell transcriptome analysis of the tumor microenvironment in angioimmunoblastic T cell lymphoma (AITL)

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive lymphoid malignancy associated with a poor clinical prognosis. The AITL tumor microenvironment (TME) is unique, featuring a minority population of mal...

Joshua C. Pritchett, Zhi-Zhang Yang, Hyo ** Kim, Jose C. Villasboas… in Leukemia (2022)

Article

Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma

Anti-PD-1 monoclonal antibodies yield high response rates in patients with relapsed/refractory classic Hodgkin lymphoma (cHL), but most patients will eventually progress. Allogeneic hematopoietic cell transpla...

Reid W. Merryman, Luca Castagna, Laura Giordano, Vincent T. Ho, Paolo Corradini… in Leukemia (2021)

Article

Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, and front line therapies have not improved overall outcomes since the advent of immunochemotherapy. By pairing DNA and gene expression data wi...

Keenan T. Hartert, Kerstin Wenzl, Jordan E. Krull, Michelle Manske… in Leukemia (2021)

Article

IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features

This study evaluates newly diagnosed IgM (6%, n = 75/1174) vs. non-IgM light chain amyloidosis patients. IgM amyloid patients had lower light chains (12.5 vs. 22.5 mg/dL; p < 0.001). Heart (56% vs. 73%, p = 0.002...

Surbhi Sidana, Daniel P. Larson, Patricia T. Greipp, Rong He, Ellen D. McPhail… in Leukemia (2020)

Article

Primary systemic amyloidosis in patients with Waldenström macroglobulinemia

Saurabh Zanwar, Jithma P. Abeykoon, Stephen M. Ansell, Morie A. Gertz… in Leukemia (2019)

Article

Trials and tribulations in primary CNS lymphoma

A minority of patients with primary central nervous system lymphoma (PCNSL) achieve a complete response to therapy and most patients have a poor prognosis. A recent randomized phase II trial demonstrated that ...

Stephen M. Ansell, S. Vincent Rajkumar in Nature Reviews Clinical Oncology (2010)