10 Result(s)
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Article
Open AccessAmygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS
The amygdala is a key region in emotional regulation, which is often impaired in psychosis. However, it is unclear if amygdala dysfunction directly contributes to psychosis, or whether it contributes to psycho...
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Article
Open AccessContribution of schizophrenia polygenic burden to longitudinal phenotypic variance in 22q11.2 deletion syndrome
While the recurrent 22q11.2 deletion is one of the strongest genetic risk factors for schizophrenia (SCZ), variability of its associated neuropsychiatric endophenotypes reflects its incomplete penetrance for p...
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Article
A normative chart for cognitive development in a genetically selected population
Certain pathogenic genetic variants impact neurodevelopment and cause deviations from typical cognitive trajectories. Understanding variant-specific cognitive trajectories is clinically important for informed ...
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Article
Open AccessAltered cortical thickness development in 22q11.2 deletion syndrome and association with psychotic symptoms
Schizophrenia has been extensively associated with reduced cortical thickness (CT), and its neurodevelopmental origin is increasingly acknowledged. However, the exact timing and extent of alterations occurring...
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Article
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion
Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic fact...
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Open AccessLong-term effects of early treatment with SSRIs on cognition and brain development in individuals with 22q11.2 deletion syndrome
Cognitive deficits in individuals at risk of psychosis represent a significant challenge for research, as current strategies for symptomatic treatment are often ineffective. Recent studies showed that atypical...
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Open AccessIdentifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS
Disruptions of white matter microstructure have been widely reported in schizophrenia. However, the emergence of these alterations during preclinical stages remains poorly understood. 22q11.2 Deletion Syndrome...
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Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS
Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship wi...
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Article
Open AccessAbnormal development of early auditory processing in 22q11.2 Deletion Syndrome
The 22q11.2 Deletion Syndrome (22q11.2 DS) is one of the highest genetic risk factors for the development of schizophrenia spectrum disorders. In schizophrenia, reduced amplitude of the frequency mismatch nega...
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Article
COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome
Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrom...
