5 Result(s)

Article

Plasmapheresis effectively abrogates severe liver toxicity of pegaspargase in a patient with acute lymphoblastic leukemia

Markus Tölle, Nicola Gökbuget, Stefan Habringer, Ulrich Keller… in Annals of Hematology (2024)

Article

Influence of corticosteroid treatment on CXCR4 expression in DLBCL

CXCR4-targeted radioligand therapy (RLT) with [¹⁷⁷Lu]Lu/[⁹⁰Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...

Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer… in EJNMMI Research (2023)

Article

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness

Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4^C1013G) that hyperactivates...

Richard Lewis, H. Carlo Maurer, Nikita Singh, Irene Gonzalez-Menendez… in Leukemia (2021)

Article

Investigation of spleen CXCR4 expression by [⁶⁸Ga]Pentixafor PET in a cohort of 145 solid cancer patients

The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter… in EJNMMI Research (2021)

Article

Response assessment with the CXCR4-directed positron emission tomography tracer [⁶⁸Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger… in EJNMMI Research (2017)