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  1. No Access

    Article

    Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

    Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants undergo normal development and show minimal changes in ge...

    Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao… in Nature Genetics (2017)

  2. No Access

    Article

    Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

    The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent clus...

    Delphine Douillet, Christie C. Sze, Caila Ryan, Andrea Piunti… in Nature Genetics (2020)