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Article
Pharmacokinetics and extensive intestinal first-pass effects of apigenin and its active metabolite, apigenin-7-O-glucuronide, in rats
This study investigated the metabolism and pharmacokinetics of apigenin and its metabolite, apigenin-7-O-glucuronide (A7G), using a newly developed UPLC-MS/MS method.
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Article
Open AccessRadiological manifestations and clinical findings of patients with oncologic and osteoporotic medication-related osteonecrosis of the jaw
Medication-related osteonecrosis of the jaw (MRONJ) poses a challenging form of osteomyelitis in patients undergoing antiresorptive therapies in contrast to conventional osteomyelitis. This study aimed to comp...
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Article
Open AccessMechanisms of Wharton’s Jelly-derived MSCs in enhancing peripheral nerve regeneration
Warton’s jelly-derived Mesenchymal stem cells (WJ-MSCs) play key roles in improving nerve regeneration in acellular nerve grafts (ANGs); however, the mechanism of WJ-MSCs-related nerve regeneration remains unc...
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Article
Distinct Prognosis of Minimal Residual Disease According to Breast Cancer Subtype in Patients with Breast or Nodal Pathologic Complete Response After Neoadjuvant Chemotherapy
Few studies have reported on patient prognosis according to residual cancer burden after neoadjuvant chemotherapy (NAC). Herein, we evaluated the survival of patients based on residual disease after NAC to ide...
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Article
Open AccessSexual orientation in transgender adults in the United States
Sexual orientation refers to a person’s enduring emotional, romantic, or sexual attractions to other people. Sexual orientation measures do not typically consider desires for, or sexual behavior with, transgen...
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Article
Open AccessNasal cavity perforation by implant fixtures: case series with emphasis on panoramic imaging of nasal cavity extending posteriorly
The nasal cavity is an important landmark when considering implant insertion into the anterior region of the maxillary arch. The perforation of implants into the nasal cavity may cause complications, such as i...
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Article
Early experience of robotic axillary lymph node dissection in patients with node-positive breast cancer
Robotic surgical systems enable surgeons to perform precise movement in the surgical field using high-resolution 3D vision and flexible robotic instruments. We aimed to evaluate the feasibility and safety of p...
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Article
Open AccessBioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation
Decellularized extracellular matrix scaffold, widely utilized for organ engineering, often undergoes matrix decomposition after transplantation and produces byproducts that cause inflammation, leading to clini...
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Article
Open AccessRedox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
Neural stem cell (NSC) maintenance and functions are regulated by reactive oxygen species (ROS). However, the mechanisms by which ROS control NSC behavior remain unclear. Here we report that ROS-dependent Igfb...
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Article
Open AccessEffectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5
Studies have reported reduced natural SARS-CoV-2 infection- and vaccine-induced neutralization against omicron BA.4/BA.5 compared with earlier omicron subvariants. This test-negative case–control study evaluat...
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Article
Open AccessGravity and magnetic anomalies of earthquake-prone areas in the southwestern Ulleung basin margin, East Sea (Sea of Japan)
Submarine earthquakes have increased in the southwestern Ulleung Basin adjacent to the Korean Peninsula. This study analyzed the gravitational and magnetic properties of the three earthquake-prone areas (Hupo ...
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Article
Design of additives with different physical properties to control nanostructures of n-type Bi2Te3 thermoelectric thin films grown by a sputtering process
We designed sputter process parameters to produce three distinct types of n-type Bi2Te3 thin films (Ni-doped, Ti-doped, and undoped) to compare the nanostructures and the thermoelectric properties. The three film...
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Open AccessAuthor Correction: Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants
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Open AccessEffectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. We conducted a test-negative case–control study to evaluate mRNA-1...
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Open AccessAuthor Correction: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia
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Article
Open AccessZika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids
Alzheimer’s disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau (p-Tau) protein in the cerebral cortex. The precise mechanisms of...
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Article
Open AccessSingle-port transaxillary robotic thyroidectomy (START): 200-cases with two-step retraction method
This study aims to report the results of a pioneering clinical study using the single-port transaxillary robotic thyroidectomy (START) for 200 patients with thyroid tumor and to introduce our novel two-step re...
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Article
Open AccessKi-67 and breast cancer prognosis: does it matter if Ki-67 level is examined using preoperative biopsy or postoperative specimen?
This study aimed to identify the association between Ki-67 level and the prognosis of patients with breast cancer, regardless of the timing of Ki-67 testing (using preoperative biopsy vs. postoperative specimen).
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Article
Open AccessWeekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. Dihydrotestosterone (DHT) and androgen receptor (AR) levels are increased in patients with AGA, and DHT-AR signaling correlate...
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Article
Open AccessAccumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease
Mitochondrial dysfunction is associated with familial Alzheimer’s disease (fAD), and the accumulation of damaged mitochondria has been reported as an initial symptom that further contributes to disease progres...
