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    Article

    Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

    Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse mutations are associated with diverse clinical phenotypes, suggesti...

    Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh… in Nature Genetics (2023)