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Article
Open AccessRisk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study
A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a CAD genetic risk score is superior to the measureme...
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Article
Open AccessAssociation between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification
To examine the association between lipoprotein(a) (Lp(a)) levels, LPA (rs10455872 and rs3798220) and IL1F9 (rs13415097) single nucleotide polymorphisms (SNPs) with coronary artery calcification (CAC), an importan...
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Article
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic...
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Article
Genetic fine map** and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine map** and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants i...
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Article
Defining the role of common variation in the genomic and biological architecture of adult human height
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci signif...
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Article
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of Europe...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
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Article
Open AccessRisk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study
Atherosclerosis is the primary cause of coronary heart disease (CHD), preceding the onset of cardiovascular disease by decades in most cases. Here we examine the association between single nucleotide polymorph...
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Article
Open AccessMicrosomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study
The microsomal triglyceride transfer protein (MTTP) is encoded by the MTTP gene that is regulated by cholesterol in humans. Previous studies investigating the effect of MTTP on ischemic heart disease have produce...