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Article
Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug
The Warburg effect refers to the phenomenon whereby cancer cells avidly take up glucose and produce lactic acid under aerobic conditions. Although the molecular mechanisms underlying tumor reliance on glycolys...
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Article
Open AccessFumarate induces redox-dependent senescence by modifying glutathione metabolism
Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. We combined analytical chemistry and metabolic computational modellin...
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Article
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH ...
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Article
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Accumulation of fumarate resulting from mutations in fumarate hydratase,which are associated with renal and other cancers, is shown to induce epithelial-to-mesenchymal transition—a process associated with canc...
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Article
Correction: Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Nature 537, 544–547 (2016); doi:10.1038/nature19353 In this Letter, the ArrayExpress accession number provided for the gene expression data for Sdhb-deficient cells should have been ‘ E-MTAB-4349’, rather than...
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Article
Mannose impairs tumour growth and enhances chemotherapy
It is now well established that tumours undergo changes in cellular metabolism1. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake2, we have been interested i...
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Article
Open AccessD-mannose suppresses macrophage IL-1β production
D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimul...
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Article
Open AccessPyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis
Succinate dehydrogenase (SDH) is the mitochondrial enzyme converting succinate to fumarate in the tricarboxylic acid (TCA) cycle. SDH acts as a tumor suppressor with germline loss-of-function mutations in its ...
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Article
Open AccessACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota
Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating...
