86 Result(s)

Article

Huperzine A Activates Wnt/β-Catenin Signaling and Enhances the Nonamyloidogenic Pathway in an Alzheimer Transgenic Mouse Model

Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy. In this study, we searched for new mechani...

Chun-Yan Wang, Wei Zheng, Tao Wang, **g-Wei **e, Si-Ling Wang… in Neuropsychopharmacology (2011)

Article

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct binding sites. Previous studies have reported that g...

Rong-Qing Chen, Shan-Hui Wang, Wen Yao, **g-**g Wang, Fang Ji… in Neuropsychopharmacology (2011)

Article

FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J

Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch a...

Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin… in BMC Cancer (2014)

Article

The effects of psychological interventions on depression and anxiety among Chinese adults with cancer: a meta-analysis of randomized controlled studies

Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on ...

Yi-Long Yang, Guo-Yuan Sui, Guang-Cong Liu, De-Sheng Huang, Si-Meng Wang… in BMC Cancer (2014)

Article

Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis

The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM).

Meng-Die Chen, Si-Si Dong, Ning-Yu Cai, Meng-Di Fan… in BMC Cardiovascular Disorders (2016)

Article

Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD).

Si-Wei Li, ** Wang, Ying Yang, Zhi-Jie Liu, Lin Cheng… in Journal of Translational Medicine (2016)

Article

Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with...

**g-**g Song, Si-Jia Zhao, Juan Fang, Da Ma, **ang-Qi Liu, **ao-Bing Chen… in BMC Cancer (2016)

Article

A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Tong Luo Hua Shi capsule, a modernized Tibetan medicine, in patients with rheumatoid arthritis

Tong Luo Hua Shi (TLHS) is a new formulation of the traditional Tibetan medicine Wu-wei-gan-lu that has been used for the treatment of rheumatoid arthritis (RA) for hundreds of years in China. This study aimed...

Wei Liu, Yuan-Hao Wu, Si-Yuan Hu, Cheng-Liang Zhong, Ming-Li Gao, Dong-Wu Liu… in Trials (2016)

Article

Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer

Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao… in BMC Cancer (2017)

Article

Erratum to: Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer

Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao… in BMC Cancer (2017)

Article

Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing b...

Shan-Shan Rao, Yin Hu, **-Li **e, Jia Cao, Zhen-**ng Wang, Jiang-Hua Liu… in Bone Research (2018)

Article

The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...

Ji-** Yao, Ya-Nan **, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou… in BMC Cancer (2018)

Article

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionalit...

Di Liu, ** Chu, Hao Wang, **g Dong, Si-Qi Ge… in Journal of Translational Medicine (2018)

Article

Establishment of a Predictive Model Related to Pathogen Invasion for Infectious Diseases and Its Diagnostic Value in Fever of Unknown Origin

The present study aimed to establish a list of parameters indicative of pathogen invasion and develop a predictive model to distinguish the etiologies of fever of unknown origin (FUO) into infectious and non-i...

Zhu-hua Wu, Ming-you **ng, Sheng Wei, Man-zhi Zhao, Wen-xia Wang… in Current Medical Science (2018)

Article

Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area

Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...

Ji-** Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen… in BMC Cancer (2019)

Article

Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF)

Subclinical hypothyroidism is a common condition in patients with heart failure and is defined as elevated serum thyroid hormone (TSH) with normal circulating free thyroxine (FT4). Evidence on the effect of th...

Xuan Zhang, Wen-yao Wang, Kuo Zhang, Jian Tian, Ji-lin Zheng, **g Chen… in Trials (2019)

Article

Pretreatment risk management of a novel nomogram model for prediction of thoracoabdominal extrahepatic metastasis in primary hepatic carcinoma

Extrahepatic metastasis is the independent risk factor of poor survival of primary hepatic carcinoma (PHC), and most occurs in the chest and abdomen. Currently, there is still no available method to predict th...

Jia Hu, Ting Wang, Kun-He Zhang, Yi-** Jiang… in Journal of Translational Medicine (2019)

Article

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (M...

Feng Wang, Ming-Ming He, Zi-**an Wang, Su Li, Ying **, Chao Ren, Si-Mei Shi… in BMC Cancer (2019)

Article

Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively harvested from unlimited and easily available urine, as a...

Chun-Yuan Chen, Shan-Shan Rao, Yi-Juan Tan, Ming-Jie Luo, **ong-Ke Hu… in Bone Research (2019)

Article

The flavonoid-rich Quzhou Fructus Aurantii extract modulates gut microbiota and prevents obesity in high-fat diet-fed mice

Flavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. In this study, we investigated the effect of Total F...

Yong-feng Bai, Si-wei Wang, **ao-xiao Wang, Yuan-yuan Weng… in Nutrition & Diabetes (2019)