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    Evaluation of Potential Antidepressant-Like Activity of Chalcone-1203 in Various Murine Experimental Depressant Models

    Two classic animal behavior despair tests-the forced swimming test (FST) and the tail suspension test (TST) were used to evaluate antidepressant-like activity of a new chalcone compound, chalcone-1203 in mice...

    Li-** Guan, Li-Ming Tang, Cheng-Yan Pan, Shui-Lian Zhao in Neurochemical Research (2014)

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    Acupoint Specificity on Colorectal Hypersensitivity Alleviated by Acupuncture and the Correlation with the Brain–Gut Axis

    This project was focused on the study of the effect of the different acupoints on visceral hypersensitivity and the correlation with the brain–gut axis. By using a mouse model of zymosan-induced colorectal hyp...

    Shao-Jun Wang, Hao-Yan Yang, Fang Wang, Si-Ting Li in Neurochemical Research (2015)

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    Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia

    Chronic neuroinflammation is a pathological feature of neurodegenerative diseases. Inhibition of microglia-mediated neuroinflammation might be a potential strategy for neurodegeneration. Matairesinol, a dibenz...

    Peng Xu, Meng-Wei Huang, Chen-** **ao, Fen Long, Ying Wang in Neurochemical Research (2017)

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    Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury

    Cerebral ischemic injury is a leading cause of human mortality and disability, seriously threatening human health in the world. Activin A (Act A), as a well-known neuroprotective factor, could alleviate ischem...

    Jiao-Qi Wang, Yue Dong, Si-Jia Li, Cheng-Liang Pan, Hong-Yu Liu in Neurochemical Research (2019)

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    A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome

    Inhibition of immune and inflammatory reaction induced by the expose of nucleus pulposus (NP) could effectively ameliorate neuropathic pain in the lumbar disc herniation. Maresin1 (MaR1), as a macrophage-deriv...

    Yi-hao Wang, Yan Li, Jun-nan Wang, Qing-xiang Zhao, Shuang Wen in Neurochemical Research (2020)

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    Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture

    Satellite glial cells (SGCs) tightly surround neurons and modulate sensory transmission in dorsal root ganglion (DRG). At present, the biological property of primary SGCs in culture deserves further investigat...

    Na Wei, Ya-** Liu, Rui-Rui Wang, Zhen-Juan Zhong in Neurochemical Research (2022)

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    Sodium Para-aminosalicylic Acid Inhibits Lead-Induced Neuroinflammation in Brain Cortex of Rats by Modulating SIRT1/HMGB1/NF-κB Pathway

    Lead (Pb) is considered to be a major environmental pollutant and occupational health hazard worldwide which may lead to neuroinflammation. However, an effective treatment for Pb-induced neuroinflammation rema...

    Yue-song Zhao, Jun-yan Li, Zhao-cong Li, Lei-lei Wang in Neurochemical Research (2023)