26 Result(s)

Article

Subunits of human condensins are potential therapeutic targets for cancers

The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are invol...

Hong-Zhen Wang, Si-Han Yang, Gui-Ying Li, Xudong Cao in Cell Division (2018)

Article

Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b

As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of...

Si-Li Wang, Yun Huang, Rui Su, Yong-Yang Yu in Cancer Cell International (2019)

Article

Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway

To investigate the role of P16 (INK4a)-extracellular signal related kinase 1/2 (ERK1/2) signaling pathway in cisplatin (DDP) resistance induced by multidrug resistance protein 1 (MDR1), also known as P-glycopr...

Yun **ao, Mei-rong Liang, Cheng-cheng Liu, Ya-nan Wang, Yang Zeng… in Cell Division (2019)

Article

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Circular RNAs (circRNAs), a novel type of noncoding RNAs, play critical roles in the initiation and progression of cancer. Emerging studies also shows that circRNAs may function as potential markers for cancer...

Dao-xiong Ye, Si-si Wang, Ying Huang, Pan Chi in Cancer Cell International (2019)

Article

CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling

Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly maligna...

Jian-**an Lin, **ong-Feng Weng, **n-Sheng **e, Ning-Zi Lian… in Cancer Cell International (2019)

Article

miR-100-3p inhibits cell proliferation and induces apoptosis in human gastric cancer through targeting to BMPR2

miR-100 has been reported to closely associate with gastric cancer (GC) initiation and progression. However, the underlying mechanism of miR-100-3p in GC is still largely unclear. In this study, we intend to s...

Chun-Wei Peng, Ling-**ao Yue, Yuan-Qin Zhou, Sai Tang… in Cancer Cell International (2019)

Article

EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin

The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repress...

Si-qi Chen, Jia-qi Li, **ao-qiao Wang, Wen-**g Lei, Hao Li, Jiao Wan… in Cell Division (2020)

Article

Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials

COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient supply. We did two single-center, randomised, double-blind, placebo-controlled phase 1 and phase 2 trials to as...

Fan-Yue Meng, Fan Gao, Si-Yue Jia… in Signal Transduction and Targeted Therapy (2021)

Article

RETRACTED ARTICLE: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance

Recent reports suggest that the long non-coding RNA LBX2 antisense RNA 1 (LBX2-AS1) acts as an important regulator in cancer progression, but its significance in colorectal cancer (CRC) remains undetermined.

Yu-Nan Ma, Yong-Gang Hong, Guan-Yu Yu, Si-yuan Jiang… in Cancer Cell International (2021)

Article

USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A_165b alternative splicing via regulating SRSF1 and SRPK1

The benefit of targeted therapy for renal cell carcinoma (RCC) is largely crippled by drug resistance. Rapid disease progression and poor prognosis occur in patients with drug resistance. New treatments demand...

**u-wu Pan, Da Xu, Wen-** Chen, Jia-xin Chen, Wei-jie Chen… in Cancer Cell International (2021)

Article

CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1

Acute myeloid leukemia (AML) is a myeloid neoplasm accounts for 7.6% of hematopoietic malignancies. AML is a complex disease, and understanding its pathophysiology is contributing to the improvement in the tre...

You Jiang, Shui-Yan Wu, Yan-Ling Chen, Zi-Mu Zhang… in Cancer Cell International (2021)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Retraction Note: LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance

Yu-Nan Ma, Yong-Gang Hong, Guan-Yu Yu, Si-yuan Jiang… in Cancer Cell International (2023)

Article

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen… in Signal Transduction and Targeted Therapy (2023)

Article

Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

**ao Liu, Fei Hao, Peng Hao, **gxue Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade

Si-Chong Han, Gui-Zhen Wang, Ya-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...

Sheng-yuan Zhang, Qiu-** Xu, Li-na Shi… in Signal Transduction and Targeted Therapy (2023)

Article

MALAT1/ mir-1-3p mediated BRF2 expression promotes HCC progression via inhibiting the LKB1/AMPK signaling pathway

The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to play a vital role in the occurrence and development of various tumors. However, the underlying mecha...

Guang-Zhen Li, Guang-**ao Meng, Guo-Qiang Pan, **ao Zhang… in Cancer Cell International (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)