1,265 Result(s)

Article

Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance

Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF)...

Lihong Pan, **aochen He, Rui Xu, Umesh Bhattarai, Ziru Niu, Jussara do Carmo… in GeroScience (2024)

Article

DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence of NAFLD has been increasing with aging for unknown reasons. Here, we investigate the ...

Mingfeng **a, Wenran Li, Huandong Lin, Hailuan Zeng, Shuai Ma, Qi Wu, Hui Ma… in GeroScience (2024)

Article

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy

Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscu...

Haibin Zhu, Huan Luo, **aowei Wu, Hangyang Bao… in Cellular and Molecular Life Sciences (2024)

Article

Specific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats

Cognitive impairment frequently presents as a prevalent consequence following stroke, imposing significant burdens on patients, families, and society. The objective of this study was to assess the effectivenes...

Mengyuan Dai, Kecheng Qian, Qinyu Ye, **ding Yang, Lin Gan… in Molecular Neurobiology (2024)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

Correction: The HDAC inhibitor, MPT0E028, enhances erlotinib induced cell death in EGFR-TKI-resistant NSCLC cells

M. -C Chen, C. -H Chen, J. -C Wang, A. -C Tsai, J. -P Liou… in Cell Death & Disease (2024)

Article

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering

Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...

Peng Cheng, Cong Mao, ** Tang, Sen Yang, Yu Cheng, Wuke Wang, Qiuxi Gu… in Cell Research (2024)

Article

The role of lncRNA NEAT1 in human cancer chemoresistance

Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become ...

Feng Long, Xue Li, **gyu Pan, Hailin Ye, Cuixia Di… in Cancer Cell International (2024)

Article

Role of ferroptosis in radiation-induced soft tissue injury

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reacti...

Charlotte E. Berry, Carter B. Kendig, Nicholas An… in Cell Death Discovery (2024)

Article

Protein SUMOylation promotes cAMP-independent EPAC1 activation

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated ...

Wenli Yang, Fang C. Mei, Wei Lin, Mark A. White… in Cellular and Molecular Life Sciences (2024)

Article

Correction: Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway

Rikito Tatsuno, Jiro Ichikawa, Yoshihiro Komohara, Cheng Pan… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Adipose-derived stem cells modified by TWIST1 silencing accelerates rat sciatic nerve repair and functional recovery

The regeneration of peripheral nerves after injury is often slow and impaired, which may be associated with weakened and denervated muscles subsequently leading to atrophy. Adipose-derived stem cells (ADSCs) a...

Bo Chen, Leining Wang, **aogui Pan, Shuai Jiang, Yihe Hu in Human Cell (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mech...

Yiman Li, Yan Song, Zhi**g Shi, Huijie Hou, Yang Yu, Fei Pan… in Cell Death & Disease (2024)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m⁶A modification

TGF-β1 plays a pivotal role in the metastatic cascade of malignant neoplasms. N6-methyladenosine (m⁶A) stands as one of the most abundant modifications on the mRNA transcriptome. However, in the metastasis of gal...

Zhenheng Wu, Qiming Ke, Lei Jiang, Haijie Hong, Wei Pan, Wen Chen… in Cell Death & Disease (2024)

Article

ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...

**ze Li, Yingli Yan, Yang Fu, Zhe Chen… in Cellular & Molecular Biology Letters (2024)

Article

Correction: Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF

Botao Pan, Can Liu, Jiyan Su, Chenglai **a in Cell Communication and Signaling (2024)

Article

BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo

Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will in...

Qihong Yang, Kenneth Kin Wah To, Guilin Hu, Kai Fu… in Cell Communication and Signaling (2024)