665 Result(s)

Article

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy

Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscu...

Haibin Zhu, Huan Luo, **aowei Wu, Hangyang Bao… in Cellular and Molecular Life Sciences (2024)

Article

Neutralizing Antibody Sample Testing and Report Harmonization

Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic. Neutralizing antibody (NAb) assays are used to characterize a p...

Darshana Jani, Michele Gunsior, Robin Marsden, Kyra J. Cowan… in The AAPS Journal (2024)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

Correction: The HDAC inhibitor, MPT0E028, enhances erlotinib induced cell death in EGFR-TKI-resistant NSCLC cells

M. -C Chen, C. -H Chen, J. -C Wang, A. -C Tsai, J. -P Liou… in Cell Death & Disease (2024)

Article

Role of ferroptosis in radiation-induced soft tissue injury

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reacti...

Charlotte E. Berry, Carter B. Kendig, Nicholas An… in Cell Death Discovery (2024)

Article

Protein SUMOylation promotes cAMP-independent EPAC1 activation

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated ...

Wenli Yang, Fang C. Mei, Wei Lin, Mark A. White… in Cellular and Molecular Life Sciences (2024)

Article

Correction: Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway

Rikito Tatsuno, Jiro Ichikawa, Yoshihiro Komohara, Cheng Pan… in Cell Death & Disease (2024)

Article

Rapid improvement of grain appearance in three-line hybrid rice via CRISPR/Cas9 editing of grain size genes

Genetic editing of grain size genes quickly improves three-line hybrid rice parents to increase the appearance quality and yield of hybrid rice.

Juan Huang, Weiwei Chen, Lijun Gao, Dong** Qing… in Theoretical and Applied Genetics (2024)

Article

Correction: LncRNA-NNT-AS1 contributes to the progression of glioma by miR-582-5p/EZH2 axis

Tonglin Pan, Min Xue in Cytotechnology (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mech...

Yiman Li, Yan Song, Zhi**g Shi, Huijie Hou, Yang Yu, Fei Pan… in Cell Death & Disease (2024)

Article

TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m⁶A modification

TGF-β1 plays a pivotal role in the metastatic cascade of malignant neoplasms. N6-methyladenosine (m⁶A) stands as one of the most abundant modifications on the mRNA transcriptome. However, in the metastasis of gal...

Zhenheng Wu, Qiming Ke, Lei Jiang, Haijie Hong, Wei Pan, Wen Chen… in Cell Death & Disease (2024)

Article

Correction: HepG2 exosomes coated luteolin nanoparticles remodeling hepatic stellate cells and combination with sorafenib for the treatment of hepatocellular carcinoma

Shengjie Ye, **er Pan, Lei Zhang, Yanlong Hong, Kaili Hu in Cancer Nanotechnology (2024)

Article

ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...

**ze Li, Yingli Yan, Yang Fu, Zhe Chen… in Cellular & Molecular Biology Letters (2024)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

A folding motif formed with an expanded genetic alphabet

Adding synthetic nucleotides to DNA increases the linear information density of DNA molecules. Here we report that it also can increase the diversity of their three-dimensional folds. Specifically, an addition...

Bang Wang, James R. Rocca, Shuichi Hoshika, Cen Chen, Zunyi Yang… in Nature Chemistry (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...

Pengfei Zhang, Ju Yang, **ong Liu, Congshu Huang, Yuandong Tao… in Cell Death & Disease (2024)

Article

Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D

Polyphyllin D (PD), one of the important steroid saponins in traditional medicinal herb Paris polyphylla, has been demonstrated to have anticancer activity both in vitro and in vivo. However, the mechanisms throu...

Chuanchao Wei, Anwei Mao, Yongzhi Liu, Qing Zhang… in Applied Biochemistry and Biotechnology (2024)