389 Result(s)

Article

Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration

The progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the occurrence of neurodegenerative diseases, but its role in PD remains poo...

Tingfu Du, Guoxiang Li, Qinglan Zong, Haiyu Luo, Yue Pan, Kaili Ma in Immunity & Ageing (2024)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

Correction: The HDAC inhibitor, MPT0E028, enhances erlotinib induced cell death in EGFR-TKI-resistant NSCLC cells

M. -C Chen, C. -H Chen, J. -C Wang, A. -C Tsai, J. -P Liou… in Cell Death & Disease (2024)

Article

Correction: Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway

Rikito Tatsuno, Jiro Ichikawa, Yoshihiro Komohara, Cheng Pan… in Cell Death & Disease (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mech...

Yiman Li, Yan Song, Zhi**g Shi, Huijie Hou, Yang Yu, Fei Pan… in Cell Death & Disease (2024)

Article

TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m⁶A modification

TGF-β1 plays a pivotal role in the metastatic cascade of malignant neoplasms. N6-methyladenosine (m⁶A) stands as one of the most abundant modifications on the mRNA transcriptome. However, in the metastasis of gal...

Zhenheng Wu, Qiming Ke, Lei Jiang, Haijie Hong, Wei Pan, Wen Chen… in Cell Death & Disease (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...

Pengfei Zhang, Ju Yang, **ong Liu, Congshu Huang, Yuandong Tao… in Cell Death & Disease (2024)

Article

Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7

Kaixuan Zeng, **aoxiang Chen, Mu Xu, **angxiang Liu, **uxiu Hu… in Cell Death & Disease (2024)

Article

A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression

Transforming growth factor beta (TGFβ) signaling plays a critical role in tumorigenesis and metastasis. However, little is known about the biological function of TGFbeta-induced lncRNA in cancer. In this study...

Shanshan Qin, Qiwei Guo, Yue Liu, **angang Zhang, Pan Huang… in Cell Death & Disease (2024)

Article

A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer

Breast cancer (BC) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. The 5-year survival rate is over 90% in BC patients, but once BC cells metastasis into distal org...

Wen-Der Lin, Chia-Hao Chang, Jhih-Kai Pan, Forn-Chia Lin… in Cell Death & Disease (2024)

Article

Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma

The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...

**n Li, Yu-Fei Pan, Yi-Bin Chen, Qian-Qian Wan, Yun-Kai Lin… in Cell Death & Disease (2024)

Article

Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2

Cisplatin (DDP)-based chemoradiotherapy is one of the standard treatments for nasopharyngeal carcinoma (NPC). However, the sensitivity and side effects of DDP to patients remain major obstacles for NPC treatme...

Feng Liu, Ling Tang, Huai Liu, Yanzhu Chen, Tengfei **ao… in Cell Death & Disease (2024)

Article

Correction: The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT

Qinqin Pan, **ao Ma, Yajie You, Yuejiao Yu, Su Fan, **aoyan Wang… in Immunity & Ageing (2024)

Article

METTL3-dependent m⁶A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging evidence underscores the importance of m⁶A modifications in various bioprocesses such as stem cell differentiatio...

Lan Ma, ** Zhou, Siyue Yao, **nyu Zhang, Ji Mao, Barbara Vona… in Cell Death & Disease (2024)

Article

OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway

Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, high mortality, and poor patient prognosis. The global burden of G...

Mingxin Ci, Gaichao Zhao, Chongyang Li, Ruochen Liu, **aosong Hu… in Cell Death & Disease (2024)

Article

Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription

Breast cancer (BC) is the most commonly diagnosed malignant tumour in females worldwide. Although remarkable advances in early detection and treatment strategies have led to decreased mortality, recurrence and...

Tao Xu, Mengqiu **ong, Qiwei Hong, Bei Pan, Mu Xu, Ying Wang… in Cell Death & Disease (2024)