12 Result(s)
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English
Biomedicine
Biomedical Engineering/Biotechnology
Si**g Pan
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Article
Open AccessCkip-1 3’UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway
Sleep deprivation (SD) has emerged as a critical concern impacting human health, leading to significant damage to the cardiovascular system. However, the underlying mechanisms are still unclear, and the develo...
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Open AccessAttSiOff: a self-attention-based approach on siRNA design with inhibition and off-target effect prediction
Small interfering RNA (siRNA) is often used for function study and expression regulation of specific genes, as well as the development of small molecule drugs. Selecting siRNAs with high inhibition and low off...
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Open AccessApolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and accompanied by chronic low-grade inflammation. Adipose tissue macr...
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Open AccessNoninvasive and affordable type 2 diabetes screening by deep learning-based risk assessment and detection using ophthalmic images inspired by traditional Chinese medicine
The global prevalence of diabetes is steadily increasing, with a high percentage of patients unaware of their disease status. Screening for diabetes is of great significance in preventive medicine and may bene...
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Open AccessCorrection: Hidden Genetic Regulation of Human Complex Traits via Brain Isoforms
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A transformer-based representation-learning model with unified processing of multimodal input for clinical diagnostics
During the diagnostic process, clinicians leverage multimodal information, such as the chief complaint, medical images and laboratory test results. Deep-learning models for aiding diagnosis have yet to meet th...
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Article
Open AccessHidden Genetic Regulation of Human Complex Traits via Brain Isoforms
Alternative splicing exists in most multi-exonic genes, and exploring these complex alternative splicing events and their resultant isoform expressions is essential. However, it has become conventional that RN...
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Open AccessTargeting bromodomain-containing proteins: research advances of drug discovery
Bromodomain (BD) is an evolutionarily conserved protein module found in 46 different BD-containing proteins (BCPs). BD acts as a specific reader for acetylated lysine residues (KAc) and serves an essential rol...
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Open AccessRecent Developments in Additive-Manufactured Intermetallic Compounds for Bio-Implant Applications
This paper reviews the recent developments of two newly developed intermetallic compounds (IMCs) of metallic glasses (MGs) and high-entropy alloys (HEAs) as potential implantable biomaterials.
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Publisher Correction to: Compression Sleeve Changes Corticomuscular Connectivity and Sensorimotor Function
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Open AccessCharacteristics of pre-metastatic niche: the landscape of molecular and cellular pathways
Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour met...
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Open AccessDevelopment of Multi-axis Motor Control Systems for Lower Limb Robotic Exoskeleton
The aim of this study was to establish a control system with multi-axis motors for a lower limb robotic exoskeleton (LLRE).
