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Article
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
With the increasing of Candida albicans infections year by year, and the widespread use of azole drugs, especially fluconazole has led to the emergence of drug resistance. Therefore, new antifungal agents are urg...
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Article
Porous block copolymer films with self-adjustable optical transmittance and passive radiative cooling
As an energy-free cooling technique, radiative cooling has garnered significant attention in the field of energy conservation. However, traditional radiative cooling films often possess static optical properti...
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Article
A correlated ferromagnetic polar metal by design
Polar metals have recently garnered increasing interest because of their promising functionalities. Here we report the experimental realization of an intrinsic coexisting ferromagnetism, polar distortion and m...
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Article
Open AccessCorrelation between immune-related adverse events and efficacy of PD-(L)1 inhibitors in small cell lung cancer: a multi-center retrospective study
Patients receiving PD-(L)1 inhibitors frequently encounter unusual side effects known as immune-related adverse events (irAEs). However, the correlation of irAEs development with clinical response in small cel...
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Article
Open AccessCervical lymph node metastasis as the first symptom of combined anaplastic thyroid carcinoma (squamous cell carcinoma) and follicular carcinoma: a case report
Anaplastic thyroid carcinoma(ATC) is a rare pathological type of thyroid malignancy. Primary squamous cell carcinoma of thyroid(PSCCT) is now considered as a subtype of ATC, hereinafter referred to as ATC-SCC ...
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Article
Open AccessIncreased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells
Identifying new targets in triple negative breast cancer (TNBC) remains critical. REG3A (regenerating islet-derived protein 3 A), a calcium-dependent lectin protein, was thoroughly investigated for its express...
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Article
Terahertz beam reconfigurable phase gradient metasurface of VO2 based on different metal–insulator transition temperatures
In this letter, by using vanadium dioxide (VO2) with metal–insulator transition (MIT) temperatures of 60 ℃ and 72 ℃, respectively, and analyzing the effects of the two states of VO2 before (insulator state) and a...
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Article
Association of serum trimethylamine N-oxide levels and bone mineral density in type 2 diabetes mellitus
The relationship between trimethylamine N-oxide (TMAO) and bone mineral density (BMD) in type 2 diabetes mellitus (T2DM) is unclear. We explore the relationship between TMAO levels and BMD in T2DM.
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Open AccessAutophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis
Macrophages (Mφ) autophagy is a pivotal contributor to inflammation-related diseases. However, the mechanistic details of its direct role in acute kidney injury (AKI) were unclear. Here, we show that Mφ promot...
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Article
Open AccessAssociation between sleep patterns and galectin-3 in a Chinese community population
Irregular sleep patterns have been associated with inflammation. Galectin-3, a novel biomarker, plays an important role in inflammation. We investigated the relationship between sleep patterns and galectin-3 i...
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Article
Open AccessObservation of dichotomic field-tunable electronic structure in twisted monolayer-bilayer graphene
Twisted bilayer graphene (tBLG) provides a fascinating platform for engineering flat bands and inducing correlated phenomena. By designing the stacking architecture of graphene layers, twisted multilayer graph...
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Article
Evolution of the flat band and the role of lattice relaxations in twisted bilayer graphene
Magic-angle twisted bilayer graphene exhibits correlated phenomena such as superconductivity and Mott insulating states related to the weakly dispersing flat band near the Fermi energy. Such a flat band is exp...
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Article
Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylases
Despite their intriguing photophysical and photochemical activities, naturally occurring photoenzymes have not yet been repurposed for new-to-nature activities. Here we engineered fatty acid photodecarboxylase...
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Article
Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors
Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit, thus rationalizing their efficient ...
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Article
Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg–3Zn–xNd Alloys
The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning...
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Article
Comparison of yield and physicochemical characteristics of tropical crop residue biochar under different pyrolysis temperatures
Large amounts of tropical crop residues are produced and discarded or burned, causing a great waste of crop residue resources and serious environmental pollution. Pyrolysis is considered an environment-friendl...
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Article
Open AccessLow TYROBP expression predicts poor prognosis in multiple myeloma
Multiple myeloma (MM) is the second most common refractory hematologic cancer. Searching for new targets and prognostic markers for MM is significant.
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Article
Open AccessElectrolyte disorders induced by six multikinase inhibitors therapy for renal cell carcinoma: a large-scale pharmacovigilance analysis
To provide evidence for optimization of multi-kinase inhibitors (MKIs) use in the clinic, we use the public database to describe and evaluate electrolyte disorders (EDs) related to various MKIs treated for ren...
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Article
Open AccessSingle-Cell RNA Sequencing Transcriptomics Revealed HCMV IE2-Related Microglia Responses in Alzheimer’s-Like Disease in Transgenic Mice
Although multiple factors are known to concur with Alzheimer’s disease (AD), the relationship between human cytomegalovirus (HCMV) and AD-like disease is unclear. Here, we propose a hypothesis that HCMV im...
