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Splice variants DNMT3B4 and DNMT3B7 overexpression inhibit cell proliferation in 293A cell line
DNA methyltransferase 3B (DNMT3B) is critical in abnormal DNA methylation patterns in cancer cells. Nearly 40 alternatively spliced variants of DNMT3B have been reported. DNMT3B4 and DNMT3B7 are two kinds of s...
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Article
Erratum to: Splice variants DNMT3B4 and DNMT3B7 overexpression inhibit cell proliferation in 293A cell line
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Article
Open Accessc-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities
Tumor necrosis factor (TNF) and Toll-like receptor (TLR)3/TLR4 activation trigger necroptotic cell death through downstream signaling complex containing receptor-interacting protein kinase 1 (RIPK1), RIPK3, an...
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Open AccessStructural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against coronavirus disease 2019 (COVID-19). W...
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Open AccessClinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
In addition to its role in cellular progression and cancer, SIRT6, a member of nicotinamide adenine dinucleotide (NAD+)-dependent class III deacylase sirtuin family, serves a variety of roles in the body's immune...
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Open AccessLoss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2
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Open AccessMutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction
Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye diseases. Here, we reported that the kri1l gene was responsible for ...