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  1. No Access

    Article

    Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles

    Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. Here we show that CD8+ memory T (TM) cells mobilize the carbamoyl phosphate (CP) metab...

    Ke Tang, Huafeng Zhang, **ghui Deng, Dianheng Wang, Shichuan Liu… in Nature Immunology (2023)

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    Article

    Role of endoplasmic reticulum stress in apoptosis induced by HK2 inhibitor and its potential as a new drug combination strategy

    Compared with normal cells, tumor cells mainly obtain energy through aerobic glycolysis. Hexokinase 2 (HK2) plays a key role in the regulation of tumor cell aerobic glycolysis, and targeting HK2 has become a n...

    Jiateng Zhong, Shuya Lu, **aoling Jia, Qian Li, Lei Liu… in Cell Stress and Chaperones (2022)