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Article
Open AccessBenefit of an action camera in endoscopy education for medical students under COVID-19
Endoscopy is an important form of clinical gastroenterology education because it gives students the opportunity to learn about diagnosis procedures and even treatment. During the COVID-19 pandemic, medical stu...
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Article
Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease
The prevalence of nonalcoholic fatty liver disease (NAFLD) and alcohol-associated/related liver disease (ALD) with metabolic syndrome is increasing globally. Metabolic syndrome and excessive alcohol consumptio...
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Article
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress
Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum (ER) stress is involved in the cell death pro...
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Article
Recurrent severe acute hepatitis caused by hypereosinophilic syndrome associated with elevated serum immunoglobulin G4 levels
A 46-year-old male was admitted to our hospital with severe acute hepatitis, hypereosinophilia, and serum immunoglobulin G4 (IgG4) elevation. Plasma exchange was performed, and he was treated by prednisolone; ...
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Article
Reply to the letter “Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?”
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Article
Loss of autophagy promotes murine acetaminophen hepatotoxicity
Previous reports indicate that mitochondrial dysfunction is essential for the development of liver injury due to acetaminophen. On the other hand, autophagy, which is a major catabolic pathway, plays a critica...
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Article
Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy
Autophagy has been reported to play a pivotal role on the replication of various RNA viruses. In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated an...
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Article
Open AccessAcute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report
Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by leukoerythroblastosis, massive splenomegaly, and increases in the reticular and collagen fibers in the bone marrow. Portal hyp...
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Chapter and Conference Paper
Role of Leptin in Pathogenesis of NASH
Increasing lines of evidence indicate that obesity is an important risk factor for the exacerbation of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Leptin, an obese gene product, is a...
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Article
Burn injury sensitizes rat Kupffer cells via mechanisms dependent on gut-derived endotoxin
Bacterial translocation occurs after thermal injury in association with intestinal barrier loss. Recently, we found that sensitization of Kupffer cells involved gut-derived endotoxin; therefore, the purpose of...
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Article
Open AccessExpression of leptin receptors in hepatic sinusoidal cells
Emerging evidence has suggested a critical role of leptin in hepatic inflammation and fibrogenesis, however, the precise mechanisms underlying the profibrogenic action of leptin in the liver has not been well ...
