7 Result(s)
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Article
Burn injury sensitizes rat Kupffer cells via mechanisms dependent on gut-derived endotoxin
Bacterial translocation occurs after thermal injury in association with intestinal barrier loss. Recently, we found that sensitization of Kupffer cells involved gut-derived endotoxin; therefore, the purpose of...
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Chapter and Conference Paper
Role of Leptin in Pathogenesis of NASH
Increasing lines of evidence indicate that obesity is an important risk factor for the exacerbation of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Leptin, an obese gene product, is a...
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Article
Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy
Autophagy has been reported to play a pivotal role on the replication of various RNA viruses. In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated an...
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Article
Loss of autophagy promotes murine acetaminophen hepatotoxicity
Previous reports indicate that mitochondrial dysfunction is essential for the development of liver injury due to acetaminophen. On the other hand, autophagy, which is a major catabolic pathway, plays a critica...
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Article
Reply to the letter “Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?”
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Article
Recurrent severe acute hepatitis caused by hypereosinophilic syndrome associated with elevated serum immunoglobulin G4 levels
A 46-year-old male was admitted to our hospital with severe acute hepatitis, hypereosinophilia, and serum immunoglobulin G4 (IgG4) elevation. Plasma exchange was performed, and he was treated by prednisolone; ...
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Article
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress
Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum (ER) stress is involved in the cell death pro...
