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Article
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation
Primary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease with an unclear pathogenesis, and there is currently no approved drug for the treatment of this disease. Iguratimod, as a novel cli...
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Article
Open AccessExciplex-forming cohost systems with 2,7-dicyanofluorene acceptors for high efficiency red and deep-red OLEDs
Two 2,7-dicyaonfluorene-based molecules 27-DCN and 27-tDCN are utilized as acceptors (A) to combine with hexaphenylbenzene-centered donors (D) TATT and DDT-HPB for probing the exciplex formation. The photophysica...
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Article
A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects
Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet-derived growth factor receptor beta (PDGFRB) gene. We report a case of a...
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Article
Open AccessSLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
Neuronal swelling is a pathological feature of stroke which contributes to the formation of cytotoxic edema. Under hypoxic condition, aberrant accumulation of sodium and chloride ions inside neurons increases ...
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Article
Recent progress in COF-based electrode materials for rechargeable metal-ion batteries
Covalent organic frameworks (COFs) have emerged as promising electrode materials for rechargeable metal-ion batteries and have gained much attention in recent years due to their high specific surface area, inh...
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Article
Open AccessA ring-like accretion structure in M87 connecting its black hole and jet
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure...
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Article
Neuroticism and patients’ depressive symptoms: a moderated mediation model of illness perception and patient-physician trust
Patients with high neuroticism are more likely to have negative perceptions of disease and to report more depressive symptoms. The important environmental factor of patient–physician trust may buffer the negat...
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Article
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China
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Chapter and Conference Paper
3D SAR Iterative Imaging Algorithm Via Joint Low-Rank and Sparsity
SAR sparse imaging based on the compressed sensing (CS) method has shown great potential for high-resolution imaging, reducing sampling rate, and denoising. However, conventional sparse imaging algorithms alwa...
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Article
Adventitial injection of HA/SA hydrogel loaded with PLGA rapamycin nanoparticle inhibits neointimal hyperplasia in a rat aortic wire injury model
Neointimal hyperplasia is a persistent complication after vascular interventions, and it is also the leading cause of vascular graft restenosis and failure after arterial interventions, so novel treatment meth...
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Article
Open AccessBinding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M
Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a secon...
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Article
Construction of heterogeneous 1T/2H MoSe2 homojunction nanosheets with excellent broad-spectrum photocatalytic activity
Broad-spectrum heterogeneous 1 T/2H MoSe2 homojunction nanosheets were prepared using single-step solvothermal process. The 1 T and 2H phase ratios in the homojunction could be controlled by adjusting the amount ...
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Article
An analytical p-y curve method based on compressive soil pressure model in sand soil
With the high-quality development of urban buildings, higher requirements are come up with for lateral bearing capacity of laterally loaded piles. Consequently, a more accurate analysis to predict the lateral ...
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Article
Open AccessPrevalence and associated factors of suicidal ideation among college students during the COVID-19 pandemic in China: a 3-wave repeated survey
The coronavirus disease 2019 (COVID-19) pandemic, a major public health crisis, harms individuals’ mental health. This 3-wave repeated survey aimed to examine the prevalence and correlates of suicidal ideation...
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Article
Open AccessThe clinical characteristics and prognosis in adult Ph negative acute lymphoblastic leukemia with TP53 aberrations
Very few reports elucidate the prognosis of patients with TP53 aberrations using both measurable residual disease (MRD) and the status of having undergone allogeneic hematopoietic stem cell transplantation (allo-...
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Article
Open AccessExosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation
Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors, including gastric cancer (GC). However, there are still many circRNAs related to GC whose functions and molecular mechani...
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Article
Open AccessThe application of tissue-engineered fish swim bladder vascular graft
Small diameter (< 6 mm) prosthetic vascular grafts continue to show very low long-term patency, but bioengineered vascular grafts show promising results in preclinical experiments. To assess a new scaffold sou...
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Article
Open AccessEfficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous lineage, not otherwise specified
Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. Management of relapse/refractory (R/R) patients is still challenging.traditional chemotherapy treatmen...
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Article
Open AccessDevelopment and characterization of a monoclonal antibody blocking human TRPM4 channel
TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4. Using a polypep...
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Article
Open AccessMacrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures
The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung diseases including chronic obstructive pulmonary disease (COPD) due to the complex microenvironment in lungs and the plast...
