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  1. No Access

    Article

    A bridged backbone strategy enables collective synthesis of strychnan alkaloids

    Bridged frameworks are of high chemical and biological significance, being ubiquitous in pharmaceutical molecules and natural products. Specific structures are usually preformed to build these rigid segments a...

    Wenqiang Zhou, Song **, Haohua Chen, Dan Jiang, Jiao Yang… in Nature Chemistry (2023)

  2. Article

    Open Access

    ACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis

    Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. With the method of RNA sequencing, we found that irradiation (IR) markedly increased the expression of ferroptosis pr...

    Qian Ji, Shengqiao Fu, Hao Zuo, Yumeng Huang, Liangmei Chu… in Cell Death Discovery (2022)

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  3. No Access

    Article

    miR-140-3p regulates the osteogenic differentiation ability of bone marrow mesenchymal stem cells by targeting spred2-mediated autophagy

    Understanding the function and regulatory mechanism of miR-140-3p on the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Alizarin Red staining, Alkaline phosphatase (ALP) staining, and ALP a...

    ** Liu, Yan Zhuang, Binfei Zhang, Hai Huang… in Molecular and Cellular Biochemistry (2021)

  4. Article

    Open Access

    A three dimensional visualisation approach to protein heavy-atom structure reconstruction

    A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates.

    Xubiao Peng, Alireza Chenani, Shuangwei Hu, Yifan Zhou… in BMC Structural Biology (2014)

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  5. No Access

    Article

    Immunohistochemical Expression of RAGE and Its Ligand (S100A9) in Cervical Lesions

    Altered expressions of receptor for advanced glycation end-products (RAGE) and its ligand (S100A9) are observed in many cancers and play a key role in inflammation-associated cancer. In our previous study, by ...

    Xuejie Zhu, Lanying **, Shuangwei Zou, Qi Shen… in Cell Biochemistry and Biophysics (2013)

  6. No Access

    Article

    An Upregulation of SENP3 After Spinal Cord Injury: Implications for Neuronal Apoptosis

    SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and function...

    Haixiang Wei, Honglin Teng, Weipeng Huan, Shuangwei Zhang… in Neurochemical Research (2012)

  7. No Access

    Article

    KPC1 Expression and Essential Role After Acute Spinal Cord Injury in Adult Rat

    KPC1 (Kip1 ubiquitylation-promoting complex 1) is the catalytic subunit of the ubiquitin ligase KPC, which regulates the degradation of the cyclin-dependent kinase inhibitor p27kip1 at the G1 phase of the cell cy...

    Jian Zhao, Shuangwei Zhang, **ujie Wu, Weipeng Huan, Zhiqiang Liu… in Neurochemical Research (2011)