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Article
Open AccessUltrasound-responsive Bi2MoO6-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer
Ovarian cancer (OC) has the highest fatality rate among all gynecological malignancies, necessitating the exploration of novel, efficient, and low-toxicity therapeutic strategies. Ferroptosis is a type of prog...
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Article
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a cytosolic multi-subunit protein complex, and recent studies have demonstrated the vital ro...
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Article
Biodegradation of mixed litter-derived dissolved organic matter with varying evenness in a temperate freshwater wetland
Litter-derived dissolved organic matter (DOM) plays an essential role in biogeochemical cycles. In wetlands, species relative abundance and its change have great influences on input features of litter-derived ...
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Article
Open AccessNicotinamide mitigates visceral leishmaniasis by regulating inflammatory response and enhancing lipid metabolism
Currently, treatment regimens for visceral leishmaniasis (VL) are limited because of the presence of numerous adverse effects. Nicotinamide, a readily available and cost-effective vitamin, has been widely ackn...
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Article
Ultrathin polyimide-based composites with efficient low-reflectivity electromagnetic shielding and infrared stealth performance
Researching and manufacturing materials that possess both electromagnetic interference (EMI) shielding and infrared stealth capabilities is of great significance. Herein, an ultrathin polyimide-based nonwoven ...
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Article
tRF-33-P4R8YP9LON4VDP inhibits gastric cancer progression via modulating STAT3 signaling pathway in an AGO2-dependent manner
It has been demonstrated that tRNA-derived small RNAs (tsRNAs) perform essential functions in the pathophysiology of cancer. In this study, we focused on the possible mechanisms of tRF-33-P4R8YP9LON4VDP (tRF-3...
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Article
Fresh Food Quality Deterioration Detection and Labeling: a Review of Recent Research and Application in Supply Chain
The demand for fresh food has become a frequent high demand commodity in everyday living and accounts for a larger share of the retail consumer market. As the quality of fresh foods deteriorates from harvest t...
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Article
A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning
Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study intro...
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Article
Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
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Article
Open AccessCoronin 2B deficiency induces nucleolar stress and neuronal apoptosis
In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limitin...
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Article
Open AccessRight ventricular function indices and platelet parameters for early prediction value of bronchopulmonary dysplasia: a retrospective study
To examine the value of early echocardiographic indices for the right ventricular function combined with platelet(PLT) parameters for predicting bronchopulmonary dysplasia (BPD) in preterm infants.
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Article
Time and value aware influence blocking maximization in geo-social networks
The influence blocking maximization (IBM) problem aims to identify the most influential set of positive nodes in a social network to prevent the propagation of negative information throughout the network. Howe...
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Article
Open AccessTanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway
Psoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the course of the disease lasts for most of the lifetime. Tanshinol (TAN) is...
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Article
Does residential photovoltaic installation matter for coal-to-electricity transition? Evidence from self-determination theory perspective
The Chinese government is steadfast in its pursuit of dual carbon goals, advocating for the expansion of residential photovoltaic power generation as a means to revolutionize rural energy consumption. Despite ...
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Article
PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway
Pancreatic cancer is difficult to manage owing to the challenges involved in its treatment and nursing. This study aimed to clarify the roles and mechanisms of action of Poly (A)-binding protein cytoplasmic 1 ...
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Article
miR-92a-3p promotes pulmonary fibrosis progression by regulating KLF2-mediated endothelial-to-mesenchymal transition
Pulmonary fibrosis (PF) is a chronic lung disease that has a poor prognosis and a serious impact on the quality of life of patients. Here, we investigated the potential role of miR-92a-3p in PF. The mRNA level...
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Article
Epstein–Barr virus positive gastric cancer: the pathological basis of CT findings and radiomics models prediction
To analyze the clinicopathologic information and CT imaging features of Epstein–Barr virus (EBV)-positive gastric cancer (GC) and establish CT-based radiomics models to predict the EBV status of GC.
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Article
Open AccessAn externally validated clinical-laboratory nomogram for myocardial involvement in adult idiopathic-inflammatory-myopathy patients
This study aimed at identifying clinical and laboratory risk factors for myocardial involvement (MI) in idiopathic inflammatory myopathies (IIMs) patients as well as constructing a risk-predicted nomogram for ...
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Article
Prenatal environmental adversity and child neurodevelopmental delay: the role of maternal low-grade systemic inflammation and maternal anti-inflammatory diet
Maternal inflammation has been proposed as a possible pathway connecting prenatal environmental adversity (PEA), which includes maternal overweightness or obesity, diabetes, hypertensive disorders, and mood or...
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Article
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review
The oceans are rich in diverse microorganisms, animals, and plants. This vast biological complexity is a major source of unique secondary metabolites. In particular, marine fungi are a promising source of comp...
