84 Result(s)

Article

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...

Chunge Zhong, Wen-Jie Jiang, Yingjia Yao, Zexu Li, You Li… in Nature Communications (2024)

Article

A real-world pharmacovigilance study of FDA adverse event reporting system events for Capmatinib

Capmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study eval...

Yiming Qi, **g Li, Sisi Lin, Shuangshuang Wu, Kequn Chai, **n Jiang… in Scientific Reports (2024)

Article

Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation

Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases. While the host immune cells do produce extracellular vesicles to counteract some deleterious effects of the microbiota...

Shuangshuang Wan, Kepeng Wang, Peihong Huang, **an Guo, Wurui Liu… in Nature Communications (2024)

Article

Author Correction: A comprehensive analysis and experimental validation of TK1 in uterine corpus endometrial carcinoma

Yiqing Sun, Kaiwen Zhang, Tianqi Wang, Shuangshuang Zhao, Chao Gao… in Scientific Reports (2024)

Article

Logistic analysis of delayed reporting of emergency blood potassium and comparison of improved outcomes

Potassium testing is an essential test in emergency medicine. Turnaround time (TAT) is the time between specimen receipt by the laboratory and the release of the test report. A brief in-laboratory TAT increase...

Jian Zhang, Shuangshuang Lv, Tingting **, **axuan Hu in Scientific Reports (2024)

Article

A comprehensive analysis and experimental validation of TK1 in uterine corpus endometrial carcinoma

Uterine corpus endometrial carcinoma (UCEC) is becoming a main malignant cancer that threaten to women's health. Thymidine kinase 1 (TK1) is considering to be associated with tumorigenesis and development. Nev...

Yiqing Sun, Kaiwen Zhang, Tianqi Wang, Shuangshuang Zhao, Chao Gao… in Scientific Reports (2024)

Article

Inorganic perovskite-based active multifunctional integrated photonic devices

The development of highly efficient active integrated photonic circuits is crucial for advancing information and computing science. Lead halide perovskite semiconductors, with their exceptional optoelectronic ...

Qi Han, Jun Wang, Shuangshuang Tian, Shen Hu, Xuefeng Wu… in Nature Communications (2024)

Article

Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1

Roundabout guidance receptor 2 (Robo2) is closely related to malignant tumors such as pancreatic cancer and liver fibrosis, but there is no relevant research on the role of Robo2 in HCC. The study will further...

Ting Liu, Congjie Zhai, Bo Tian, Chao Li, Shuangshuang Han… in Scientific Reports (2024)

Article

Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma

Cytokine release syndrome (CRS) is the most common complication of chimeric antigen receptor redirected T cells (CAR-T) therapy. CAR-T toxicity management has been greatly improved, but CRS remains a prime saf...

Shuangshuang Yang, Jie Xu, Yuting Dai, Shiwei **, Yan Sun… in Nature Communications (2024)

Article

Identification of a cancer associated fibroblasts-related index to predict prognosis and immune landscape in ovarian cancer

Cancer-associated fibroblasts (CAFs) play a role in ovarian cancer (OV) evolution, immunosuppression and promotion of drug resistance. Exploring the value of CAFs-related biomarker in OV is of great importance...

Yingquan Ye, Shuangshuang Zhang, Yue Jiang, Yi Huang, Gaoxiang Wang… in Scientific Reports (2023)

Article

Research on blasting mechanism and blasting effect of aqueous media in open pit coal mines

Surface coal mining procedures include piercing—blasting—mining and loading—transportation—discharging, blasting link exists due to the poor blasting effect leads to low loading efficiency, blasting dust cause...

**aohua Ding, **n Liu, Zhongchen Ao, Hao Qin, **aoshuang Li… in Scientific Reports (2023)

Article

Author Correction: Sustained antidepressant effect of ketamine through NMDAR trap** in the LHb

Shuangshuang Ma, Min Chen, Yihao Jiang, **nkuan **ang, Shiqi Wang, Zuohang Wu… in Nature (2023)

Article

Sustained antidepressant effect of ketamine through NMDAR trap** in the LHb

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist¹, has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects^2–4. Although the elimination half-l...

Shuangshuang Ma, Min Chen, Yihao Jiang, **nkuan **ang, Shiqi Wang, Zuohang Wu… in Nature (2023)

Article

Estimating residual undifferentiated cells in human chemically induced pluripotent stem cell derived islets using lncRNA as biomarkers

Human pluripotent stem cells (hPSCs) can generate insulin-producing beta cells for diabetes treatment, but residual undifferentiated cells may cause tumors. We developed a highly sensitive assay to detect thes...

Yandan Wu, Zhenzhen Zhang, Shuangshuang Wu, Zhaolong Chen, Yue Pu in Scientific Reports (2023)

Article

The impact of education and digitalization on female labour force participation in BRICS: an advanced panel data analysis

The present study empirically elucidates the interconnections between digitalization and FLFP in BRICS economies. Furthermore, we also assessed the influence of three essential economic indicators on FLFP, i.e...

Yu Shuangshuang, Wenzhong Zhu… in Humanities and Social Sciences Communicati… (2023)

Article

Control of arbuscule development by a transcriptional negative feedback loop in Medicago

Most terrestrial plants establish a symbiosis with arbuscular mycorrhizal fungi (AMF), which provide them with lipids and sugars in exchange for phosphorus and nitrogen. Nutrient exchange must be dynamically c...

Qiang Zhang, Shuangshuang Wang, Qiu** **e, Yuanjun **a, Lei Lu… in Nature Communications (2023)

Article

Non cancer causes of death after gallbladder cancer diagnosis: a population-based analysis

Mortality from non cancer causes in patients with gallbladder cancer (GBC) still unclear. This study evaluated the causes and risk factors of non cancer death during different follow-up periods after GBC diagn...

Yang **a, Shuangshuang Lu, Chunyan Huo, Li Fan, Min Lin, ** Huang in Scientific Reports (2023)

Article

Evaluation on coupling coordinated development of population economy and eco-geological environment in the twin-city economic circle of Chengdu–Chongqing region

Using the CRITIC method, comprehensive index evaluation method, VAR model, coupling coordination model and other methods, this paper evaluates the comprehensive development of the population economy and eco-ge...

Dong Han, Liang Chen, Hao Wu, **nyuan Wang, Yi **ao, Haonan Yang… in Scientific Reports (2023)

Article

PXL1 and SERKs act as receptor–coreceptor complexes for the CLE19 peptide to regulate pollen development

Gametophyte development in angiosperms occurs within diploid sporophytic structures and requires coordinated development; e.g., development of the male gametophyte pollen depends on the surrounding sporophytic...

Ying Yu, Wen Song, Nuo Zhai, Shiting Zhang, Jianzheng Wang… in Nature Communications (2023)

Article

Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration

It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered re...

Yan **ng, Shan Liang, Limei Zhang, He Ni, Xueqin Zhang… in Scientific Reports (2023)