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Open AccessGenetic diversity and prevalence of emerging Rickettsiales in Yunnan Province: a large-scale study
Rickettsia and related diseases have been identified as significant global public health threats. This study involved comprehensive field and systematic investigations of various rickettsial organisms in Yunna...
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Article
Open AccessThe mouse multi-organ proteome from infancy to adulthood
The early-life organ development and maturation shape the fundamental blueprint for later-life phenotype. However, a multi-organ proteome atlas from infancy to adulthood is currently not available. Herein, we ...
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Article
Open AccessAdvances of Synergistic Electrocatalysis Between Single Atoms and Nanoparticles/Clusters
Fundamental principles for designing synergistic composite catalysts are reviewed.
The synergistic effect between various ac...
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Article
Open AccessFluorinated chlorin chromophores for red-light-driven CO2 reduction
The utilization of low-energy photons in light-driven reactions is an effective strategy for improving the efficiency of solar energy conversion. In nature, photosynthetic organisms use chlorophylls to harvest...
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Article
Open AccessClinical application of targeted next-generation sequencing in severe pneumonia: a retrospective review
The precise identification of the underlying causes of infectious diseases, such as severe pneumonia, is essential, and the development of next-generation sequencing (NGS) has enhanced the effectiveness of pat...
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Article
Open AccessAdvanced enhancement technique for infrared images of wind turbine blades utilizing adaptive difference multi-scale top-hat transformation
Enhancing infrared images is essential for detecting wind turbine blades using infrared technology. This paper introduces an Infrared Image Enhancement Method based on Adaptive Iterative Cutoff Threshold Diffe...
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Article
Open AccessCorrection: Longitudinal strain correlates with 6-minute walk distance whereas ejection fraction and diastolic parameters do not
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Article
Open AccessBiomarkers to predict efficacy of immune checkpoint inhibitors in colorectal cancer patients: a systematic review and meta-analysis
Immune checkpoint inhibitors (ICIs) are approved to treat colorectal cancer (CRC) with mismatch-repair gene deficiency, but the response rate remains low. Value of current biomarkers to predict CRC patients’ r...
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Article
Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Article
Retraction Note: Designing of CuS growing on Bi2WO6 nanosheet heterostructures based on a photoelectrochemical aptasensor for detecting ofloxacin
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Article
Open AccessAssociation of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome
Hypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation and aggregability are closely related to hypercoagulability in nephro...
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Article
Open AccessAssociation between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS
Circulating atherogenic index of plasma (AIP) levels has been proposed as a novel biomarker for dyslipidemia and as a predictor of insulin resistance (IR) risk. However, the association between AIP and the inc...
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Article
Open AccessDirammox-dominated microbial community for biological nitrogen removal from wastewater
Direct ammonia oxidation (Dirammox) might be of great significance to advance the innovation of biological nitrogen removal process in wastewater treatment systems. However, it remains unknown whether Dirammox...
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Article
Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
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Article
Open AccessBi-regional dynamic contrast-enhanced MRI for prediction of microvascular invasion in solitary BCLC stage A hepatocellular carcinoma
To construct a combined model based on bi-regional quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), as well as clinical-radiological (CR) features for predicting microvascular invas...
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Article
Open AccessHome‑rearing environment and preschoolers’ academic and behavioral competence: The indirect role of children’s screen time
The home-rearing environment (HRE) is significantly related to preschoolers’ academic and behavioral development. Children’s screen time has become an increasingly important aspect of the family environment in...
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Article
Open AccessSingle-molecule reconstruction of eukaryotic factor-dependent transcription termination
Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we use single-molecule fluorescence...
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Article
Open AccessPCK1-mediated glycogenolysis facilitates ROS clearance and chemotherapy resistance in cervical cancer stem cells
Cervical cancer, one of the most common gynecological cancers, is primarily caused by human papillomavirus (HPV) infection. The development of resistance to chemotherapy is a significant hurdle in treatment. I...
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Article
Open AccessProgrammable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies
Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to enhance antitumor effects and offers emerging opportunities for treating invasive tumor indications such as melanoma. H...
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Article
Open AccessA comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common primary liver cancer with a high incidence and mortality. Members of the growth-arresting-specific 2 (GAS2) family are involved in various biological processes in hum...
