35 Result(s)

Article

Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study

Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...

**aozhong Chen, Wei Wang, Qingfeng Zou… in Signal Transduction and Targeted Therapy (2024)

Article

Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1

RNA-binding proteins (RBPs) are critical regulators for RNA transcription and translation. As a key member of RBPs, ELAV-like family protein 2 (CELF2) has been shown to regulate RNA splicing and embryonic hema...

Tengxiao Guo, Yuxia Wang, **aolu Sun, Shuaibing Hou, Yanjie Lan, Shengnan Yuan… in Oncogene (2024)

Article

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and ins...

Wei-Wei Liu, Si-Qing Zheng, Tian Li… in Signal Transduction and Targeted Therapy (2024)

Article

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction...

Yan Sun, **u-Na Yang, Shuang-Shuang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice

Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population. Given the increased incidence of cancer and the population ageing trend globally, it i...

Yi Liu, Yanhong Ji, Ruiyi Jiang, Chao Fang… in Signal Transduction and Targeted Therapy (2023)

Article

Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits

Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal role of abDGCs in recurrent seizures o...

Liying Chen, Yingwei Xu, Heming Cheng… in Signal Transduction and Targeted Therapy (2023)

Article

Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure network. Previous studies have primarily focused on the disrupt...

Yang Zheng, Cenglin Xu, **yi Sun, Wenjie Ming… in Signal Transduction and Targeted Therapy (2023)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Protein acylation: mechanisms, biological functions and therapeutic targets

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the progress of metabonomics and proteomi...

Shuang Shang, **g Liu, Fang Hua in Signal Transduction and Targeted Therapy (2022)

Article

A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors

Sheng Liu, Chunyan Wei, Tian Liu… in Signal Transduction and Targeted Therapy (2022)

Article

Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway

Dexamethasone (Dex), as a pretreatment agent, is widely used to attenuate the side effects of chemotherapy in breast cancer treatment. However, whether and how Dex affects breast cancer metastasis remain to be...

Yu**g Zhang, Gang Shi, Hantao Zhang, Qi **ong, Fuyi Cheng, Huiling Wang… in Oncogene (2021)

Article

Signaling of MK2 sustains robust AP1 activity for triple negative breast cancer tumorigenesis through direct phosphorylation of JAB1

Triple negative breast cancer (TNBC) cells are generally more invasive than estrogen receptor-positive (ER + ) breast cancer cells. Consistent with the importance of activator protein 1 (AP1) transcription fac...

Haoming Chen, Ravi Padia, Tao Li, Yue Li, Bin Li, Lingtao **… in npj Breast Cancer (2021)

Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

Huijie Bian, Zhao-Hui Zheng, Ding Wei… in Signal Transduction and Targeted Therapy (2021)

Article

Correction to: Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01652-5

Guanwen Wang, Juan Wang, Antao Chang, Dongmei Cheng, Shan Huang, Dan Wu… in Oncogene (2021)

Article

BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells

The basic leucine zipper ATF-like transcription factor 2 (BATF2) has been implicated in inflammatory responses and anti-tumour effects. Little, however, is known regarding its extracellular role in maintaining...

**n Zhang, Yi Liu, Lei Dai, Gang Shi, Jie Deng, Qiang Luo, Qian **e, Lin Cheng… in Oncogene (2021)