42 Result(s)
within
Shu-yang **ang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAn important functional group, benzo[1,3]dioxole, of alkaloids induces the formation of the human telomeric DNA G-quadruplex
Over the past few decades, numerous molecules have been discovered or designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Some of these molecules have been develo...
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Article
Proximity-induced high-temperature superconductivity in the topological insulators Bi2Se3 and Bi2Te3
Interest in the superconducting proximity effect has been reinvigorated recently by novel optoelectronic applications as well as by the possible emergence of the elusive Majorana fermion at the interface betwe...
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Open AccessCentrifugation-assisted Assembly of Colloidal Silica into Crack-Free and Transferrable Films with Tunable Crystalline Structures
Self-assembly of colloidal particles into colloidal films has many actual and potential applications. While various strategies have been developed to direct the assembly of colloidal particles, fabrication of ...
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Article
Open AccessSequence features associated with the cleavage efficiency of CRISPR/Cas9 system
The CRISPR-Cas9 system has recently emerged as a versatile tool for biological and medical research. In this system, a single guide RNA (sgRNA) directs the endonuclease Cas9 to a targeted DNA sequence for site...
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Article
Open AccessResponse of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite
Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of ost...
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Article
Open AccessCCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlap**, fatal neurodegenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated pro...
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Article
Open AccessMK2 inhibitor reduces alkali burn-induced inflammation in rat cornea
MK2 activation by p38 MAPK selectively induces inflammation in various diseases. We determined if a MK2 inhibitor (MK2i), improves cornea wound healing by inhibiting inflammation caused by burning rat corneas ...
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Open AccessThe acquisition of Clostridium tyrobutyricum mutants with improved bioproduction under acidic conditions after two rounds of heavy-ion beam irradiation
End-product inhibition is a key factor limiting the production of organic acid during fermentation. Two rounds of heavy-ion beam irradiation may be an inexpensive, indispensable and reliable approach to increa...
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Article
Open AccessSerotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease
Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and...
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Article
Open AccessPhenotype of postural instability/gait difficulty in Parkinson disease: relevance to cognitive impairment and mechanism relating pathological proteins and neurotransmitters
Parkinson disease (PD) is identified as tremor-dominant (TD) and postural instability and gait difficulty (PIGD) phenotypes. The relationships between motor phenotypes and cognitive impairment and the underlyi...
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Article
Open AccessDescemet’s Membrane Supports Corneal Endothelial Cell Regeneration in Rabbits
Descemet’s membrane (DM) helps maintain phenotype and function of corneal endothelial cells under physiological conditions, while little is known about the function of DM in corneal endothelial wound healing p...
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Article
Open AccessRestless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters
Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 patients into PD with an...
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Article
Open AccessSha** micro-clusters via inverse jamming and topographic close-packing of microbombs
Designing topographic clusters is of significant interest, yet it remains challenging as they often lack mobility or deformability. Here we exploit the huge volumetric expansion (up to 3000%) of a new type of ...
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Open AccessIron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance
Parkinson disease (PD) is associated with multiple factors, including iron, which is demonstrated to deposit excessively in PD brains. We detected iron deposition by susceptibility weighted image (SWI) and mea...
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Article
Origin and differentiation of human memory CD8 T cells after vaccination
The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We used in vivo deut...
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Open AccessParkinson disease with constipation: clinical features and relevant factors
Constipation is one of the most frequent non-motor symptoms of Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not to be reported in time. The relationships between constip...
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Open AccessTT(N)mGCCTC inhibits archaeal family B DNA polymerases
The proofreading activity of the archaeal family B DNA polymerases enables PCR with high fidelity. However, thermostable proofreading DNA polymerases occasionally failed to amplify target fragment that could b...
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Article
Thickness-independent capacitance of vertically aligned liquid-crystalline MXenes
The scalable and sustainable manufacture of thick electrode films with high energy and power densities is critical for the large-scale storage of electrochemical energy for application in transportation and st...
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Open AccessNao**nTong Capsules inhibit the development of diabetic nephropathy in db/db mice
Nao**nTong Capsule (NXT), a Chinese medicine, is currently used to treat patients with cardiovascular and cerebrovascular diseases. Clinical observations indicate its anti-diabetic functions with unclear mecha...
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Open AccessProgramming emergent symmetries with saddle-splay elasticity
The director field adopted by a confined liquid crystal is controlled by a balance between the externally imposed interactions and the liquid’s internal orientational elasticity. While the latter is usually co...
