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Article
Negative symptoms and neurocognition in drug-naïve schizophrenia: moderating role of plasma neutrophil gelatinase-associated lipocalin (NGAL) and interferon-gamma (INF-γ)
Previous studies reported that peripheral inflammation was associated with cognitive performance and brain structure in schizophrenia. However, the moderating effect of inflammation has not been extensively st...
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Article
Open AccessPredictors of futile recanalization after endovascular treatment of acute ischemic stroke
Endovascular therapy (EVT) is the most successful treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. However, futile recanalization (FR) se...
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Article
Open AccessProtein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Pathological forms of Tar-DNA binding protein-43 (TDP-43), involving its mislocalisation to the cytoplasm and ...
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Article
Open AccessC9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD
Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72 (C9orf72) gene are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both ...
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Article
The role of isomeric alkyl chains of polymer donors on charge-transfer processes in non-fullerene organic photovoltaics: a theoretical investigation
To investigate the effects of polymer donors with isomeric alkyl chains on the interfacial charge-transfer (CT) processes, the rates of exciton dissociation (kED) and charge recombination (kCR) have been calculat...
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Article
Open AccessNanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer
Nanocarrier delivery of small interfering RNAs (siRNAs) to silence cancer-associated genes is a promising method for cancer treatment. Here, we explored the role and mechanisms of PLAG NPs-delivered si-Notch1 ...
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Article
Construction and Analysis of a Mitochondrial Metabolism-Related Prognostic Model for Breast Cancer to Evaluate Survival and Immunotherapy
As one of the most prevalent malignancies among women, breast cancer (BC) is tightly linked to metabolic dysfunction. However, the correlation between mitochondrial metabolism-related genes (MMRGs) and BC rema...
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Article
Storage, form, and influencing factors of karst inorganic carbon in a carbonate area in China
Carbonate rock chemical weathering carbon sinks reduce the rate of increase of the atmospheric CO2 concentration and global warming. However, uncertainty still exists in the estimation results of carbonate rock c...
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Article
Open AccessRecent advance of microbial mercury methylation in the environment
Methylmercury formation is mainly driven by microbial-mediated process. The mechanism of microbial mercury methylation has become a crucial research topic for understanding methylation in the environment. Pion...
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Article
Open Accessm6A-methylated KCTD21-AS1 regulates macrophage phagocytosis through CD47 and cell autophagy through TIPR
Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis for lung canc...
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Article
Open AccessPhosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome
The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular events, including growth, differentiation, and motility. A major mechanism of downregulating EGFR function involves its en...
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Article
Open AccessUse of Pharmacokinetic and Pharmacodynamic Data to Develop the CDK4/6 Inhibitor Ribociclib for Patients with Advanced Breast Cancer
Ribociclib is an orally bioavailable, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. CDK4/6 inhibition by ribociclib leads to retinoblastoma tumor suppressor protein (Rb) reactivation, thereby r...
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Article
Open AccessAPC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation
The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...
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Article
Investigation of dislocation and twinning behavior in HMX under high-velocity impact employing molecular dynamics simulations
Under the ReaxFF/lg force field, the multiscale shock technique (MSST) was employed to investigate the decomposition behavior of perfect, dislocated, and twinned octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocin...
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Article
Open AccessApproaching expert-level accuracy for differentiating ACL tear types on MRI with deep learning
Treatment for anterior cruciate ligament (ACL) tears depends on the condition of the ligament. We aimed to identify different tear statuses from preoperative MRI using deep learning-based radiomics with sex an...
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Chapter and Conference Paper
Vertical GaN Junction Barrier Schottky Diode with p-NiO/n-GaN Hetero-Junction
Selective-area p-type do** in GaN has been regarded as one of the key challenges for vertical junction-based GaN devices. Nickel oxide (NiO) has been demonstrated as a p-type semiconductor and has shown grea...
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Article
Transforming membrane distillation to a membraneless fabric distillation for desalination
Membrane distillation (MD), an emerging thermal desalination technology for more than five decades, has not been widely commercialized largely due to the use of hydrophobic membranes. Here we introduce fabric ...
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Article
Open AccessInhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis
Metabolic reprogramming to glycolysis is closely associated with the development of chronic kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a rate-limiting enzyme in gly...
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Article
Open Access17-year follow-up of association between telomere length and all-cause mortality, cardiovascular mortality in individuals with metabolic syndrome: results from the NHANES database prospective cohort study
The relationship between leukocyte telomere length (LTL) and mortality risk in individuals with metabolic syndrome (MetS) remains poorly understood. This study aimed to investigate the association between telo...
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Article
Open AccessALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation
Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F...
