30 Result(s)
within
Shu-Wen **a
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessElectrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification
Electrooxidation has emerged as an increasingly viable platform in molecular syntheses that can avoid stoichiometric chemical redox agents. Despite major progress in electrochemical C−H activations, these aren...
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Open AccessReaction performance prediction with an extrapolative and interpretable graph model based on chemical knowledge
Accurate prediction of reactivity and selectivity provides the desired guideline for synthetic development. Due to the high-dimensional relationship between molecular structure and synthetic function, it is ch...
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Open AccessData-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis
Challenging enantio- and diastereoselective cobalt-catalyzed C–H alkylation has been realized by an innovative data-driven knowledge transfer strategy. Harnessing the statistics of a related transformation as ...
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Article
Open AccessSTUB1 is an intracellular checkpoint for interferon gamma sensing
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identif...
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Open AccessFunctional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer
MYB proteins are highly conserved DNA-binding domains (DBD) and mutations in MYB oncoproteins have been reported to cause aberrant and augmented cancer progression. Identification of MYB molecular biomarkers p...
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Open AccessBinding interaction of a ring-hydroxylating dioxygenase with fluoranthene in Pseudomonas aeruginosa DN1
Pseudomonas aeruginosa DN1 can efficiently utilize fluoranthene as its sole carbon source, and the initial reaction in the biodegradation process is catalyzed by a ring-hydroxylating dioxygenase (RHD). To clarify...
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Open AccessInfluenza vaccination and the risk of COVID-19 infection and severe illness in older adults in the United States
The coronavirus disease of 2019 (COVID-19) has caused a global pandemic and led to nearly three million deaths globally. As of April 2021, there are still many countries that do not have COVID-19 vaccines. Bef...
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Open AccessPublisher Correction: Association between pet ownership and physical activity levels, atopic conditions, and mental health in Singapore: a propensity score-matched analysis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessCD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis
A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT...
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Open AccessAssociation between pet ownership and physical activity levels, atopic conditions, and mental health in Singapore: a propensity score-matched analysis
Although existing literature increasingly suggests a positive influence of pet ownership on human physical activity levels, results from many European, American, and Japanese studies have been inconsistent. Ho...
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Open AccessAsymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma
Macular retinal layer thickness asymmetry indices, particularly for the ganglion cell layer, are promising early indicators of glaucomatous damage. We evaluated macular perfusion density asymmetry (MPDA) among...
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Open AccessImmunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased pr...
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Open AccessCataract surgery reduces intraocular pressure but not posture-induced intraocular pressure changes in patients with angle-closure glaucoma
Cataract surgery leads to a sustained decrease in sitting intraocular pressure (IOP) in patients with angle-closure glaucoma (ACG). The purpose of this study is to evaluate whether cataract surgery can also re...
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Open AccessDevelopment and Validation of a Risk Scoring System for Cephamycin-Associated Hemorrhagic Events
Cephamycin-associated hemorrhages have been reported since their launch. This research aimed to determine risk factors for cephamycin-associated hemorrhagic events and produce a risk scoring system using Natio...
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Open AccessMechanism of Interleukin-4 Reducing Lipid Deposit by Regulating Hormone-Sensitive Lipase
Accumulating evidence indicates that inflammation participates in the pathophysiological progress from insulin resistance, obesity, metabolic abnormalities, and type 2 diabetes mellitus. Our previous study rev...
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Open AccessSiNWs Biophysically Regulate the Fates of Human Mesenchymal Stem Cells
While biophysical stimuli from polymeric matrices are known to significantly affect the fates of human mesenchymal stem cells (hMSCs), the stimulatory effects of nano-sized silicon-based matrices on hMSCs have...
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Open AccessPrediction of plasma efavirenz concentrations among HIV-positive patients taking efavirenz-containing combination antiretroviral therapy
We investigated the predictors of plasma mid-dose concentrations (C12) of efavirenz by enrolling 456 HIV-positive patients who had received 2 nucleos(t)ide reverse-transcriptase inhibitors plus efavirenz (600 ...
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Open AccessLong-term use of ceftriaxone sodium induced changes in gut microbiota and immune system
Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics....
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Open AccessResveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection
Dengue is one of the most significant mosquito-borne virus diseases worldwide, particularly in tropical and subtropical regions. This study sought to examine the antiviral activity of resveratrol (RESV), a phy...
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Open AccessKIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte
KIF2A, a member of the kinesin-13 family, has been reported to play a role in spindle assembly in mitosis. However, its function in mammalian meiosis remains unknown. In this research, we examined the expressi...
