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Article
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Article
Early Therapeutic Drug Monitoring Optimizes Teicoplanin Use in Febrile Neutropenic Patients with Hematological Malignancies
A target trough concentration (Cmin) of teicoplanin ≥ 15–20 mg/L between the fourth and sixth day has been suggested for severe infections or management of febrile neutropenia (FN). Owing to no reports discussing...
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Article
Opportunities for production and property research of neutron-rich nuclei around N = 126 at HIAF
The study of nuclide production and its properties in the \({N}=126\) N ...
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Article
Synergistic rare-earth yttrium single atoms and copper phosphide nanoparticles for high-selectivity ammonia electrosynthesis
Electrochemical nitrate reduction to NH3 holds a great promise for N-upcycling in nature, while its sluggish reaction kinetics involved in both the stepwise deoxygenation and hydrogenation processes necessitates ...
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Article
A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon MgO–C bricks by introducing ZrSiO4
Conventional MgO–C bricks (graphite content > 14 wt.%) produce a great deal of greenhouse gas emission, while low-carbon MgO–C bricks have serious thermal shock resistance during high-temperature service. To e...
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Article
Design and prototy** of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility
The high energy cosmic-radiation detection (HERD) facility is planned to launch in 2027 and scheduled to be installed on the China Space Station. It serves as a dark matter particle detector, a cosmic ray inst...
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Article
Effect of Nb-content on the corrosion resistance of Co-free high entropy alloys in chloride environment
This study investigated the effect of Nb-content on the corrosion behavior of the $${\text{Al}}_{7}{{\text{Cr}}}_{20}{{\text{Fe}}}_{\text{35} - {{x}}}...
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Article
Open AccessAberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such...
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Article
Open AccessDe novo variants of IRF2BPL result in developmental epileptic disorder
Pathogenic variants of the IRF2BPL gene have been reported to cause neurodevelopmental disorders; however, studies focused on IRF2BPL in zebrafish are limited.
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Article
Integrated Bioinformatic Analysis and Validation Identifies Immune Microenvironment-Related Potential Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, accompanied by cognitive and memory impairment, accounting for about 60% - 80% of dementia types. The pathogenesis of AD has not b...
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Article
Open AccessThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...
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Article
Open AccessSimultaneous assessment of stress hyperglycemia ratio and glycemic variability to predict mortality in patients with coronary artery disease: a retrospective cohort study from the MIMIC-IV database
Stress hyperglycemia and glycemic variability (GV) can reflect dramatic increases and acute fluctuations in blood glucose, which are associated with adverse cardiovascular events. This study aimed to explore w...
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Article
Open AccessChildhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis
Adverse childhood experiences (ACEs), including childhood maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between chi...
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Article
Technological diversity in the tropical-subtropical zone of Southwest China during the terminal Pleistocene: excavations at Fodongdi Cave
The terminal Pleistocene witnessed significant paleoclimatic changes that influenced the adaptive behavior of human populations. Situated in the tropical-subtropical zone of Southwest China, a newly excavated ...
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Chapter and Conference Paper
Reunderstanding and Potential Exploration Effect of Yangta 5 Reservoir
Yangta 5 Cretaceous reservoir was known to be a massive reservoir with bottom water in the early stage. It has good production effect, but it shows the dynamic and static contradiction of water in high parts a...
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Chapter and Conference Paper
Method Research and Application of Strip** Strong Reflection of Igneous Rock Based on Forward and Inverse
The strong reflection signal of igneous rock has a great shielding effect on its above and below reservoirs, often resulting in poor effect of reservoir prediction. How to strip the strong reflection signal to...
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Article
Open AccessTriosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry
Although great progress has been made in anti-cancer therapy, the prognosis of laryngeal squamous cell carcinoma (LSCC) patients remains unsatisfied. Quantities of studies demonstrate that glycolytic reprogram...
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Article
Effect of heat treatment on corrosion resistance and antibacterial ability of 0Cr15Ni5Cu3Mo carbon steel
Before and after heat treatment, 0Cr15Ni5Cu3MoN stainless steel (SS) samples were immersed in sulfate-reducing bacteria (SRB) environment to study the effect of heat treatment on the antimicrobial properties o...
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Article
Implementation costs of sugary drink policies in the United States
To support implementation of important public health policies, policymakers need information about implementation costs over time and across stakeholder groups. We assessed implementation costs of two federal ...
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Article
Simulation of a soft-gamma-ray polarimeter on board a microsatellite
Gamma-ray polarimetry is a new and prospective tool for studying extremely high-energy celestial objects and is of great significance for the field of astrophysics. With the rapid development of microsatellite...
