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  1. Article

    Open Access

    Helicobacter pylori-induced gastric cancer is orchestrated by MRCKβ-mediated Siah2 phosphorylation

    Helicobacter pylori-mediated gastric carcinogenesis is initiated by a plethora of signaling events in the infected gastric epithelial cells (GECs). The E3 ubiquitin ligase seven in absentia homolog 2 (Siah2) is i...

    Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah… in Journal of Biomedical Science (2021)

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  2. Article

    Open Access

    Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

    Contractile actomyosin bundles are key force-producing and mechanosensing elements in muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and mechanism regulating their contractility a...

    Shrikant B. Kokate, Katarzyna Ciuba, Vivien D. Tran, Reena Kumari… in Nature Communications (2022)

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  3. Article

    Open Access

    Focal adhesions contain three specialized actin nanoscale layers

    Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, wh...

    Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate… in Nature Communications (2024)

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