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  1. Article

    Open Access

    Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

    Contractile actomyosin bundles are key force-producing and mechanosensing elements in muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and mechanism regulating their contractility a...

    Shrikant B. Kokate, Katarzyna Ciuba, Vivien D. Tran, Reena Kumari in Nature Communications (2022)

  2. Article

    Open Access

    Focal adhesions contain three specialized actin nanoscale layers

    Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, wh...

    Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate in Nature Communications (2024)