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    Translation inhibition corrects aberrant localization of mutant alanine-glyoxylate aminotransferase: possible therapeutic approach for hyperoxaluria

    Primary hyperoxaluria type 1 is a severe kidney stone disease caused by abnormalities of the peroxisomal alanine-glyoxylate aminotransferase (AGT). The most frequent mutation G170R results in aberrant mitochon...

    Ruth Belostotsky, Roman Lyakhovetsky, Michael Y. Sherman… in Journal of Molecular Medicine (2018)