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  1. Article

    Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

    In the version of this Article originally published, the authors mistakenly used the same images for three different time points in Fig. 2d: images for 24 h post-IR WT were also used for 0 h post-IR WT (top ro...

    Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, **njian Li… in Nature Cell Biology (2018)

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  2. Article

    Open Access

    Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm

    Despite rapid advancement in generation of large-scale microarray gene expression datasets, robust multigene expression signatures that are capable of guiding the use of specific therapies have not been routin...

    Daniel J. McGrail, Curtis Chun-Jen Lin… in npj Systems Biology and Applications (2017)

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  3. No Access

    Article

    Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

    Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that exposure to ionizing ra...

    Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, **njian Li… in Nature Cell Biology (2015)

  4. Article

    Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response

    Ataxia telangiectasia mutated (ATM) mediates DNA damage response by controling irradiation-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not com...

    Hong-Jen Lee, Li Lan, Guang Peng, Wei-Chao Chang, Ming-Chuan Hsu… in Cell Research (2015)

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  5. No Access

    Article

    BRIT1/MCPH1 links chromatin remodelling to DNA damage response

    Chromatin decondensation is required for repair factors to access damaged DNA. BRIT1/MCPH1, a damage response protein mutated in microcephaly, recruits the chromatin remodelling complex SWI/SNF to sites of DNA...

    Guang Peng, Eun-Kyoung Yim, Hui Dai, Andrew P. Jackson… in Nature Cell Biology (2009)

  6. No Access

    Article

    TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

    TRF2 is a member of the telosome/shelterin complex, which helps maintain telomere integrity. Using an oriented peptide library based on a previously identified TRF2-interaction region to define a consensus seq...

    Hyeung Kim, Ok-Hee Lee, Huawei **n, Liuh-Yow Chen… in Nature Structural & Molecular Biology (2009)

  7. No Access

    Article

    Localizing the EGF receptor - Reply

    Lilly Bourguignon, Keng-hsueh Lan, Patrick Singleton, Shiaw-Yih Lin… in Nature Cell Biology (2002)

  8. No Access

    Article

    Nuclear localization of EGF receptor and its potential new role as a transcription factor

    Epidermal growth factor receptor (EGFR) has been detected in the nucleus in many tissues and cell lines. However, the potential functions of nuclear EGFR have largely been overlooked. Here we demonstrate that ...

    Shiaw-Yih Lin, Keishi Makino, Weiya **a, Angabin Matin, Yong Wen… in Nature Cell Biology (2001)