22 Result(s)
within
Shiaw-Yih Lin
English
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Article
Open AccessMutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response
Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The ...
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Article
Open AccessTumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic ...
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Article
Open AccessRole of DNA repair defects in predicting immunotherapy response
Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defect...
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Article
Open AccessPBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and response to ICB in renal cell carcinoma (RCC) rem...
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Article
Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
A defective homologous recombination (HR) repair program increases tumor incidence as well as providing a survival advantage in patients with breast and ovarian cancers. Here we hypothesize that the tumor-prom...
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Article
Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
In the version of this Article originally published, the authors mistakenly used the same images for three different time points in Fig. 2d: images for 24 h post-IR WT were also used for 0 h post-IR WT (top ro...
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Article
Open AccessMulti-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
To realize the full potential of immunotherapy, it is critical to understand the drivers of tumor infiltration by immune cells. Previous studies have linked immune infiltration with tumor neoantigen levels, bu...
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Article
Open AccessImproved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm
Despite rapid advancement in generation of large-scale microarray gene expression datasets, robust multigene expression signatures that are capable of guiding the use of specific therapies have not been routin...
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Reference Work Entry In depth
BRIT1 Gene
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Article
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that exposure to ionizing ra...
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Article
Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response
Ataxia telangiectasia mutated (ATM) mediates DNA damage response by controling irradiation-induced foci formation, cell cycle checkpoint, and apoptosis. However, how upstream signaling regulates ATM is not com...
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Living Reference Work Entry In depth
BRIT1 Gene
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Article
Genome-wide transcriptome profiling of homologous recombination DNA repair
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that ...
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Article
Open AccessTumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention
In past decades, cancer patient survival has been improved with earlier detection and advancements in therapy. However, many patients who exhibit no clinical symptoms after frontline therapy subsequently suffe...
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Reference Work Entry In depth
BRIT1 Gene
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Article
BRIT1/MCPH1 links chromatin remodelling to DNA damage response
Chromatin decondensation is required for repair factors to access damaged DNA. BRIT1/MCPH1, a damage response protein mutated in microcephaly, recruits the chromatin remodelling complex SWI/SNF to sites of DNA...
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Article
DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment
Mammalian cells are frequently at risk of DNA damage from multiple sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor the integrity of their genome. Conceptually, DDR pa...
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Article
TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs
TRF2 is a member of the telosome/shelterin complex, which helps maintain telomere integrity. Using an oriented peptide library based on a previously identified TRF2-interaction region to define a consensus seq...
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Reference Work Entry In depth
BRIT1 Gene
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Article
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