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  1. No Access

    Article

    Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression

    A defective homologous recombination (HR) repair program increases tumor incidence as well as providing a survival advantage in patients with breast and ovarian cancers. Here we hypothesize that the tumor-prom...

    Tao Lin, Tsung-Chin Lin, Daniel J. McGrail, Parnit K. Bhupal, Yi-Hsuan Ku… in Oncogene (2019)

  2. Article

    Open Access

    Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention

    In past decades, cancer patient survival has been improved with earlier detection and advancements in therapy. However, many patients who exhibit no clinical symptoms after frontline therapy subsequently suffe...

    Sih-han Wang, Shiaw-Yih Lin in Experimental Hematology & Oncology (2013)

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    Article

    DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment

    Mammalian cells are frequently at risk of DNA damage from multiple sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor the integrity of their genome. Conceptually, DDR pa...

    Yulong Liang, Shiaw-Yih Lin, F. Charles Brunicardi, John Goss… in World Journal of Surgery (2009)

  4. No Access

    Chapter

    Retinoblastoma Protein, Gene Expression, and Cell Cycle Control

    Regulation of cell proliferation is achieved by the tight control of the progression through the cell cycle which controls the transition of cells between quiescent and growing states. This regulation relies o...

    Jane Clifford Azizkhan, Shiaw Yih Lin, David Jensen, Dusan Kostic… in Cancer Genes (1996)