251 Result(s)
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Shi-** Zhu
Life Sciences
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Article
Open AccessPhase separation of RNF214 promotes the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...
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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Open AccessMiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice
Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for incre...
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Open AccessProstaglandin I2 signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice
Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I2 (PGI2) can prevent the process of fibrosis in various tissue...
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Clinical analysis of DNA methylation in the diagnosis of cervical lesions
Currently, cervical cancer screening is primarily conducted through liquid-based thin-layer cytology (TCT) and HPV testing. However, TCT has low sensitivity, leading to a high false-negative rate. Although HPV...
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Open AccessSingle-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma
Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. ...
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Open AccessRoot-to-shoot signaling positively mediates source-sink relation in late growth stages in diploid and tetraploid wheat
Non-hydraulic root source signaling (nHRS) is a unique positive response to soil drying in the regulation of plant growth and development. However, it is unclear how the nHRS mediates the tradeoff between sour...
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Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be determined. Here we conducted a large-scale whole-exome-sequencing st...
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Arabidopsis Sar1b is critical for pollen tube growth
Pollen tube growth is an essential step leading to reproductive success in flowering plants, in which vesicular trafficking plays a key role. Vesicular trafficking from endoplasmic reticulum to the Golgi appar...
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Open AccessCellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
Diabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil stasis, resulting in retinal inflammation and the occlusion of retinal mi...
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Open AccessALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p
Circular RNAs (circRNAs) have recently been suggested as potential functional modulators of cellular physiology processes in gastric cancer (GC). In this study, we demonstrated that circFOXP1 was more highly e...
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Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
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Iodine Excess May Lead to Low Exam Score in Children Aged 8–10 Years
Recent research has shown that iodine excess may damage children’s intelligence. Years of monitoring results in Shanghai show the iodine status has approached the upper limit of the appropriate range for child...
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Open AccessWhole-genome sequencing and analysis of Chryseobacterium arthrosphaerae from Rana nigromaculata
Chryseobacterium arthrosphaerae strain FS91703 was isolated from Rana nigromaculata in our previous study. To investigate the genomic characteristics, pathogenicity-related genes, antimicrobial resistance, and ph...
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Open AccessPRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, ...
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Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
The E3 ubiquitin ligase Tripartite-motif 3 (TRIM3) is known to play a crucial role in tumor suppression in various tumors through different mechanisms. However, its function and mechanism in ovarian cancer hav...
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Identification of an adult attractant for Anomala corpulenta by the reverse chemical ecology approach
Semiochemicals are dominant cues for insects to locate food, mates, predators, and oviposition sites. In the modern genomic era, semiochemicals have been identified not only by the conventional chemical ecolog...
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A fused hybrid enzyme of 8-hydroxygeraniol oxidoreductase (8HGO) from Gardenia jasminoides and iridoid synthase (ISY) from Catharanthus roseus significantly enhances nepetalactol and iridoid production
The operation of 8HGO–ISY fusion enzymes can increase nepetalactol flux to iridoid biosynthesis, and the Gj8HGO–CrISY expression in Gardenia jasminoides indicates that seco-iridoids and closed-ring iridoids share...
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Open AccessTranscription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma
Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not al...
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Effects of dietary betaine supplementation on growth performance, feed intake, intestinal histology, lipid metabolism, and immune response of black tiger shrimp (Penaeus monodon) fed diets containing two levels of raw feed attractants
To assess the effects of dietary betaine supplementation on growth performance, feed intake, intestine histology, lipid metabolism, and immune response of Penaeus monodon fed diets containing low and high levels ...
