40 Result(s)
within
Life Sciences
Microbiology
Shi ** Chen
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Article
Rearrangement in the regulation of sigD gene expression promotes 4-hydroxyisoleucine production in Corynebacterium glutamicum
Corynebacterium glutamicum is widely used in the production of amino acids. C. glutamicum possesses seven sigma factors, among which SigD is responsible for the transcription of genes involved in the synthesis of...
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Article
Open AccessThe therapeutic value of bifidobacteria in cardiovascular disease
There has been an increase in cardiovascular morbidity and mortality over the past few decades, making cardiovascular disease (CVD) the leading cause of death worldwide. However, the pathogenesis of CVD is mul...
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Article
Bacterial communities associated with mushrooms in the Qinghai-Tibet Plateau are shaped by soil parameters
Fungi capable of producing fruit bodies are essential food and medicine resources. Despite recent advances in the study of microbial communities in mycorrhizospheres, little is known about the bacterial commun...
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Antimicrobial Substances and Mechanisms of Lactobacillus rhamnosus against Gardnerella vaginalis
Bacterial vaginosis (BV) is a common vaginal disease associated with abnormal changes in the vaginal microbiome. Our previous study found that Lactobacillus rhamnosus has a good therapeutic effect on bacterial va...
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Article
Regulated synthesis and metabolism of Monascus pigments in a unique environment
Microbial fermentation in extreme environments is the focus of research, which provides new insights for the production and application of Monascus pigments. In this paper, the regulation of Monascus pigments met...
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Article
Strategies for anti-oxidative stress and anti-acid stress in bioleaching of LiCoO2 using an acidophilic microbial consortium
High metal ion concentrations and low pH cause severely inhibit the activity of an acidophilic microbial consortium (AMC) in bioleaching. This work investigated the effects of exogenous spermine on biofilm for...
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Article
Open AccessModular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production
5-aminolevulinic acid (ALA) has broad potential applications in the medical, agricultural and food industries. Several strategies have been implemented successfully to try to improve ALA synthesis. Nonetheless...
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Article
Open AccessIdentification of a novel immunological epitope on Hexon of fowl adenovirus serotype 4
Fowl adenovirus serotype 4 (FAdV-4), the causative agent of hepatitis-hydropericardium syndrome (HHS), distributed widely in the poultry farms in China. Hexon is one of the major capsid proteins associated wit...
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Article
Open AccessCharacteristics of and risk factors for biliary pathogen infection in patients with acute pancreatitis
Infection in patients with acute pancreatitis, especially severe acute pancreatitis patients, is a common and important phenomenon, and the distributions and drug resistance profiles of bacteria causing biliar...
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Article
Open AccessThe Arabidopsis spliceosomal protein SmEb modulates ABA responses by maintaining proper alternative splicing of HAB1
Abscisic acid (ABA) signaling is critical for seed germination and abiotic stress responses in terrestrial plants. Pre-mRNA splicing is known to regulate ABA signaling. However, the involvement of canonical sp...
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Article
Pseudomonas pratensis sp. nov., Isolated from Grassland Soil from Inner Mongolia, China
A novel bacterial strain, designated MHJ-10JT, was isolated from a soil sample obtained from a grassland in Inner Mongolia, China. MHJ-10JT strain could grow at 4–37 °C (optimum: 30 °C) and pH 4–9 (optimum: pH 6)...
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Article
Rational modification of the carbon metabolism of Corynebacterium glutamicum to enhance l-leucine production
l-Leucine is an essential amino acid that has wide and expanding applications in the industry. It is currently fast-growing market demand that provides a powerful impetus to further increase its bioconversion p.....
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Article
Nanobody against PDL1
Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein (PD1/PDCD1). PDL1 is a member of B7 family of immune molecules and...
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Article
Characterization of recombinant glutathione reductase from Antarctic yeast Rhodotorula mucilaginosa
Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide, which helps to maintain a cellular reducing environment during stress in organisms. However, GR of polar yeast has not been well-cha...
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Article
Optimization of Nutrient Composition for Producing ACE Inhibitory Peptides from Goat Milk Fermented by Lactobacillus bulgaricus LB6
Hypertension is a serious threat to human health and food-derived angiotensin converting enzyme (ACE; EC 3.4.15.1) inhibitory peptides can be used to regulate high blood pressure without side effects. The comp...
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Article
Bacterial community in cold and alkaline environments of Hoh **l basin in Qinghai–Tibet Plateau and isolation of potential sources of microbiota
The Hoh **l basin is the largest Cenozoic sedimentary basin in the Qinghai–Tibet Plateau (QTP) with an average altitude of above 5000 m. It is also the coldest region in the QTP. However, due to the difficulty...
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Article
Open AccessInvolvement of a dihydrodipicolinate synthase gene (FaDHDPS1) in fungal development, pathogenesis and stress responses in Fusarium asiaticum
Dihydrodipicolinate synthase (DHDPS) is an allosteric enzyme, which catalyzes the first unique step of lysine biosynthesis in prokaryotes, higher plants and some fungi. To date, the biological roles of DHDPS i...
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Article
Delivery of Helicobacter pylori HpaA to gastrointestinal mucosal immune sites using Lactococcus lactis and its immune efficacy in mice
To develop a safe and effective oral vaccine against Helicobacter pylori using its HpaA protein expressed in Lactococcus lactis.
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Article
Genetic engineering to alter carbon flux for various higher alcohol productions by Saccharomyces cerevisiae for Chinese Baijiu fermentation
Higher alcohols significantly influence the quality and flavor profiles of Chinese Baijiu. ILV1-encoded threonine deaminase, LEU1-encoded α-isopropylmalate dehydrogenase, and LEU2-encoded β-isopropylmalate dehydr...
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Article
Genetic variation and phylogenetic relationships of the ectomycorrhizal Floccularia luteovirens on the Qinghai-Tibet Plateau
Floccularia luteovirens, as an ectomycorrhizal fungus, is widely distributed in the Qinghai-Tibet Plateau. As an edible fungus, it is famous for its unique flavor. Former studies ...
