90 Result(s)

Article

Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy

The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...

Huanying Shi, Lu Chen, Tianxiao Wang, Wenxin Zhang, Jiafeng Liu… in Cell Death Discovery (2024)

Article

E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA

Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...

Yunyan Du, Zhangjian Yang, Hao Shi, Zhihan Chen, Rong Chen… in Cell Death & Disease (2024)

Article

Inter- and trans-generational impacts of real-world PM_2.5 exposure on male-specific primary hypogonadism

Exposure to PM_2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...

**aoyu Wei, Zhonghao Zhang, Yayun Gu, Rong Zhang, Jie Huang, Feng Li… in Cell Discovery (2024)

Article

Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders

Cardio-metabolic disorders (CMDs) are common in aging people and are pivotal risk factors for cardiovascular diseases (CVDs). Inflammation is involved in the pathogenesis of CVDs and aging, but the underlying ...

Siting Wu, Yulin Li, Xue Zhao, Fu-Dong Shi, **gshan Chen in Clinical Proteomics (2024)

Article

Improved therapeutic consistency and efficacy of CD317⁺ MSCs through stabilizing TSG6 by PTX3

Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma… in Stem Cell Research & Therapy (2024)

Article

Transplantation of the LRP1^high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demons...

Jiacheng Shen, Li Wu, **aoying Shi, Gang Chen, Tingwei Liu… in Stem Cell Research & Therapy (2024)

Article

Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway

Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we found that advanced oxidation protein products (AOPPs) in plasma...

**ng-Yu Zhou, Yun-Hui Lai, Jun Zhang, Ying Li, **ao-Min Wu… in Cell Death & Disease (2024)

Article

Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension

Nuclear protein 1 (Nupr1) is a multifunctional stress-induced protein involved in the regulation of tumorigenesis, apoptosis, and autophagy. However, its role in pulmonary hypertension (PH) after METH exposure...

Jie Zhou, Dan Guo, Zhen-Zhen Xu, Jia-Shun Liao, **ao-Ting Li… in Cell Biology and Toxicology (2024)

Article

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incomplet...

Kexi Yang, Juntao Li, **ghan Zhu, Yuqi Chen, Yuxin He, Jiayu Wang… in Cell Death Discovery (2024)

Article

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification

Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown. Here, we found that HES1 expression was significantly ...

Jiayu Wang, Mengxin Zhu, **ghan Zhu, Juntao Li, **ngchao Zhu… in Cell Death Discovery (2023)

Article

Allergen-induced CD11c + dendritic cell pyroptosis aggravates allergic rhinitis

Pyroptosis is crucial for controlling various immune cells. However, the role of allergen-induced CD11c + dendritic cell (DC) pyroptosis in allergic rhinitis (AR) remains unclear.

Yue-Long Qiao, Ming-Wan Zhu, Shan Xu, Wo-Er Jiao… in Cell Communication and Signaling (2023)

Article

Retraction Note: LncRNA TLR8-AS1 suppresses miR-34a maturation in hepatocellular carcinoma to suppress cell proliferation and migration

**n Shi, Hu Chen, Wei Wang, Bingzheng Yan, Zhikai Yang, **gpo Zhang in Mammalian Genome (2023)

Article

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI. DEAD-bo...

Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen… in Cell Death & Disease (2023)