17 Result(s)
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Article
Open AccessStarfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs
Spatially resolved gene expression profiling provides insight into tissue organization and cell–cell crosstalk; however, sequencing-based spatial transcriptomics (ST) lacks single-cell resolution. Current ST a...
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Open AccessGenomic insight into the origin, domestication, dispersal, diversification and human selection of Tartary buckwheat
Tartary buckwheat, Fagopyrum tataricum, is a pseudocereal crop with worldwide distribution and high nutritional value. However, the origin and domestication history of this crop remain to be elucidated.
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Open AccessGeneralizedDTA: combining pre-training and multi-task learning to predict drug-target binding affinity for unknown drug discovery
Accurately predicting drug-target binding affinity (DTA) in silico plays an important role in drug discovery. Most of the computational methods developed for predicting DTA use machine learning models, especia...
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Open AccessA reappraisal of the phylogenetic placement of the Aquilegia whole-genome duplication
The accurate placement of an ancient whole-genome duplication (WGD) in relation to the lineage divergence is important. Here, we re-investigated the Aquilegia coerulea WGD and found it is more likely lineage-spec...
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Rational modification of the carbon metabolism of Corynebacterium glutamicum to enhance l-leucine production
l-Leucine is an essential amino acid that has wide and expanding applications in the industry. It is currently fast-growing market demand that provides a powerful impetus to further increase its bioconversion p.....
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Genome-Wide Analysis of NAC Transcription Factors and Characterization of the Cold Stress Response in Sweet Osmanthus
Sweet osmanthus (Osmanthus fragrans) is an evergreen aromatic woody tree widely used in landsca**. However, O. fragrans is very sensitive to cold stress, which seriously limits its cultivation and application i...
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Genome-wide identification and characterization of long non-coding RNAs during differentiation of visceral preadipocytes in rabbit
Emerging evidence suggests that long non-coding RNAs (lncRNAs) are critical regulators of diverse biological processes, including adipogenesis. Despite being considered an ideal animal model for studying adipo...
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Open AccessCorrection to: Towards pixel-to-pixel deep nucleus detection in microscopy images
Following publication of the original article [1], we have been notified of a few errors in the html version:
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Open AccessTowards pixel-to-pixel deep nucleus detection in microscopy images
Nucleus or cell detection is a fundamental task in microscopy image analysis and supports many other quantitative studies such as object counting, segmentation, tracking, etc. Deep neural networks are emerging...
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Open AccessThe within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy
Combination therapy is one of the most effective tools for limiting the emergence of drug resistance in pathogens. Despite the widespread adoption of combination therapy across diseases, drug resistance rates ...
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Article
Reduced production of diacetyl by overexpressing BDH2 gene and ILV5 gene in yeast of the lager brewers with one ILV2 allelic gene deleted
Diacetyl causes an unwanted buttery off-flavor in lager beer. The production of diacetyl is reduced by modifying the metabolic pathway of yeast in the beer fermentation process. In this study, BDH2 and ILV5 genes...
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Open AccessImproving RNA-Seq expression estimation by modeling isoform- and exon-specific read sequencing rate
The high-throughput sequencing technology, RNA-Seq, has been widely used to quantify gene and isoform expression in the study of transcriptome in recent years. Accurate expression measurement from the millions...
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Physiological and Molecular Responses to Salt Stress in Wild Emmer and Cultivated Wheat
Salinity severely influences growth and grain yield of wheat. Modern breeding efforts have contributed to severe loss of genetic diversity and reduced tolerance to salt stress in cultivated plants. Wild emmer ...
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Open AccessMicroarray platform consistency is revealed by biologically functional analysis of gene expression profiles
Several different microarray platforms are available for measuring gene expression. There are disagreements within the microarray scientific community for intra- and inter-platform consistency of these platfor...
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Article
Cloning, Expression, and Characterization of Rice α-Galactosidase
We have successfully cloned an α-galactosidase gene from a rice cDNA library and transformed it into Escherichia coli BL21. It was subsequently cloned to the pPIC9K vector and expressed in Pichia pastoris. A sele...
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Article
Open AccessPhylophenetic properties of metabolic pathway topologies as revealed by global analysis
As phenotypic features derived from heritable characters, the topologies of metabolic pathways contain both phylogenetic and phenetic components. In the post-genomic era, it is possible to measure the "phyloph...
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Article
A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture
Production of lutein by the green microalga Chlorella protothecoides grown heterotrophically in a fermentor using glucose as the carbon source and urea as the nitrogen source was investigated. An unstructured kin...
