312 Result(s)
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Shi ** Chen
Life Sciences
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Article
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG per...
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Predicting the potential deterioration of Barrett’s esophagus based on gut microbiota: a Mendelian randomization analysis
Esophageal adenocarcinoma (EAC) is one of the most malignant tumors in the digestive system. To make thing worse, the scarcity of treatment options is disheartening. However, if detected early, there is a poss...
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Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications
Telomere length is a putative biomarker of aging and is associated with multiple age-related diseases. There are limited data on the landscape of rare genetic variations in telomere length. Here, we systematic...
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Open AccessHydrogen sulfide activates calcium signaling to confer tolerance against selenium stress in Brassica rapa
Se (selenium) pollution is an emerging environmental concern. Excessive Se induces phytotoxicity. The endogenous H2S (hydrogen sulfide) was involved in plant adaptation to Se stress, but the signaling player of H
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Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be determined. Here we conducted a large-scale whole-exome-sequencing st...
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Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study
Considerable uncertainty remains regarding the associations of multiple factors with brain health. We aimed to conduct an exposome-wide association study on neurodegenerative disease and neuropsychiatry disord...
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Crop Straws with Contrasting C/N Ratios Affect the Organic Carbon Turnover and Its Net Sequestration Efficiency When Solely or Jointly Incorporated to a Fertilized Soil
The quality (carbon to nitrogen ratio; C/N ratio) of crop residue affects the decomposition of soil organic carbon (SOC) due to the nutrient stoichiometry, which requires well-exploration especially on the dyn...
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Phosphorus deficiency regulates the growth and photophysiology responses of an economic macroalga Gracilariopsis lemaneiformis to ocean acidification and warming
Ocean acidification and warming caused by elevated CO2 are urgent problems facing the marine ecological environment. With the strengthening of environmental governance in China, anthropogenic inputs of terrestria...
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Rearrangement in the regulation of sigD gene expression promotes 4-hydroxyisoleucine production in Corynebacterium glutamicum
Corynebacterium glutamicum is widely used in the production of amino acids. C. glutamicum possesses seven sigma factors, among which SigD is responsible for the transcription of genes involved in the synthesis of...
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Open AccessNur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy
The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...
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Open AccessE3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...
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Sequence and epigenetic variations of R2R3-MYB transcription factors determine the diversity of taproot skin and flesh colors in different cultivated types of radish (Raphanus sativus L.)
This study found that three paralogous R2R3-MYB transcription factors exhibit functional divergence among different subspecies and cultivated types in radish.
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Open AccessInter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism
Exposure to PM2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...
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Open AccessMultiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders
Cardio-metabolic disorders (CMDs) are common in aging people and are pivotal risk factors for cardiovascular diseases (CVDs). Inflammation is involved in the pathogenesis of CVDs and aging, but the underlying ...
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Open AccessThe novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases
Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal lipid metabolism as a critical factor in PF pathogenesis. Our l...
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The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Despite its crucial role in the regulation of vital metabolic and neurological functions, the genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate genome-wide association st...
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Neurotransmitter norepinephrine regulates chromatosomes aggregation and the formation of blotches in coral trout Plectropomus leopardus
Color changes and pattern formations can represent strategies of the utmost importance for the survival of individuals or of species. Previous studies have associated capture with the formation of blotches (ar...
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PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model
Age-related macular degeneration (AMD) is the leading cause of irreversible vision damage among elderly individuals. There is still no efficient treatment for dry AMD. Retinal pigment epithelial (RPE) degenera...
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Open AccessImproved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3
Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...
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Hepatoprotective effects of oligochitosan on hybrid groupers (Epinephelus lanceolatu ♂ × Epinephelus fuscoguttatus ♀) against Vibrio harvey infection via suppressing apoptosis-related pathways
Oligochitosan (OCS) has many vital bioactive functions; however, its underlying mechanisms in the liver of hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatu ♂) are not well studied. A comprehen...
