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  1. Article

    Open Access

    ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

    Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the polyubiquitination process. However, the molecular mechanism a...

    Shengjun Geng, Wen Peng, Xue Wang, **aosong Hu, Hanghua Liang in Cell Death & Disease (2022)

  2. No Access

    Article

    CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression

    CBX3, also known as HP1γ, is a major isoform of heterochromatin protein 1, whose deregulation has been reported to promote the development of human cancers. However, the molecular mechanism of CBX3 in glioblas...

    Wen Peng, Shuang Shi, Jiacheng Zhong, Hanghua Liang, Jianbin Hou, **aosong Hu in Oncogene (2022)

  3. Article

    Open Access

    ZC3H15 promotes gastric cancer progression by targeting the FBXW7/c-Myc pathway

    Zinc finger CCCH-type containing 15 (ZC3H15), a highly conserved eukaryotic protein, which was associated with several cellular processes and was ubiquitously expressed in various human tissues. Recent studies...

    Jianbing Hou, Pan Huang, Chao Lan, Shengjun Geng, Minghao Xu in Cell Death Discovery (2022)