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Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion

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  1. Article

    Open Access

    Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

    Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs)...

    Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang in Journal of Neuroinflammation (2022)

  2. Article

    Open Access

    URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

    Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms ...

    Shao-Hua Su, Yi-Fang Wu, Qi Lin, Da-Peng Wang, Jian Hai in Journal of Neuroinflammation (2019)

  3. Article

    Open Access

    Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion

    URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH...

    Shao-Hua Su, Yi-Fang Wu, Da-Peng Wang, Jian Hai in Cell Death & Disease (2018)

  4. Article

    Open Access

    Effects of statins-use for patients with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials

    Aneurysmal subarachnoid hemorrhage (aSAH)-induced cerebral vasospasm and delayed ischemic neurological deficit (DIND) are the major causes of morbidity and mortality in patients with aSAH. The effects of stati...

    Shao-Hua Su, Wei Xu, Jian Hai, Yi-Fang Wu, Fei Yu in Scientific Reports (2014)